PUBLICATION
Genetic engineering of Minnesota superfish
- Authors
- Hackett, P.B.
- ID
- ZDB-PUB-970102-10
- Date
- 1996
- Source
- SAAS bulletin, biochemistry and biotechnology 9: 69-76 (Journal)
- Registered Authors
- Hackett, Perry B.
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified*
- DNA, Recombinant
- Female
- Fishes/genetics*
- Genetic Engineering*
- Growth Hormone/genetics
- Male
- Transfection
- Zebrafish/genetics
- PubMed
- 8652135
Citation
Hackett, P.B. (1996) Genetic engineering of Minnesota superfish. SAAS bulletin, biochemistry and biotechnology. 9:69-76.
Abstract
There is a chronic need to develop growth-enhanced fish for aquaculture. To meet this need we have developed techniques for genetically engineering fish to grow larger and faster. We found that the major difficulty in genetically engineering fish is the extremely high rate of mosaicism due to the late integration of transgenes into the genome. This delay also reduces the chances of passage of the transgene through the germ line. Consequently, we have engineered new vectors and mechanisms for accelerating the rate of integration of exogenous DNA into fish chromosomes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping