PUBLICATION
Target recognition in neurogenesis: formation of the Mauthner axon cap
- Authors
- Kimmel, C.B., Sessions, S.K., and Kimmel, R.J.
- ID
- ZDB-PUB-961014-598
- Date
- 1979
- Source
- Proceedings of the National Academy of Sciences of the United States of America 76(9): 4691-4694 (Journal)
- Registered Authors
- Kimmel, Charles B., Kimmel, Reida J.
- Keywords
- none
- MeSH Terms
-
- Ambystoma/embryology*
- Animals
- Axons/ultrastructure
- Brain/embryology*
- Embryonic Induction
- Fishes/embryology*
- Microscopy, Electron
- PubMed
- 291997 Full text @ Proc. Natl. Acad. Sci. USA
Citation
Kimmel, C.B., Sessions, S.K., and Kimmel, R.J. (1979) Target recognition in neurogenesis: formation of the Mauthner axon cap. Proceedings of the National Academy of Sciences of the United States of America. 76(9):4691-4694.
Abstract
To learn whether presence of a specific neuron, the Mauthner (M) cell, is required for the organization, during embryogenesis, of an associated synaptic neuropil, the M-axon cap, M-cell precursors were experimentally deleted in embryos of the zebra fish (Brachydanio rerio) and the axolotl (Ambystoma mexicanum). Examination of early larvae revealed that in about half of the cases M-axon caps were present in the absence of the corresponding M-cells. The locations and structures of such caps were approximately normal. We conclude that the M-cell is not a necessary target for normal development of the axon cap.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping