PUBLICATION
Retinoic acid-induced duplication of the zebrafish retina
- Authors
- Hyatt, G.A., Schmitt, E.A., Marsh-Armstrong, N.R., and Dowling, J.E.
- ID
- ZDB-PUB-961014-473
- Date
- 1992
- Source
- Proceedings of the National Academy of Sciences of the United States of America 89: 8293-8297 (Journal)
- Registered Authors
- Dowling, John E., Hyatt, George, Schmitt, Ellen
- Keywords
- none
- MeSH Terms
-
- Animals
- Antibodies, Monoclonal
- Morphogenesis/drug effects
- Pigment Epithelium of Eye/cytology
- Retina/embryology*
- Retinal Ganglion Cells/cytology
- Tretinoin/pharmacology*
- Zebrafish
- PubMed
- 1518861 Full text @ Proc. Natl. Acad. Sci. USA
Citation
Hyatt, G.A., Schmitt, E.A., Marsh-Armstrong, N.R., and Dowling, J.E. (1992) Retinoic acid-induced duplication of the zebrafish retina. Proceedings of the National Academy of Sciences of the United States of America. 89:8293-8297.
Abstract
Exogenous treatment of zebrafish embryos with retinoic acid induces a duplication of the retinas during development. These effects occur only when retinoic acid is applied within a 2-hr period prior to and during the initial formation of the optic primordia, and they are concentration-dependent. Light microscopic examination reveals that the second retina derives from cells in the ventral region of the developing eyecup that normally become pigment epithelial cells. Two distinct ganglion cell fields are usually observed in eyes with duplicated retinas. Bundles of axons from each ganglion cell field join as they leave the eye and innervate the contralateral tectum.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping