PUBLICATION
A pioneering growth cone in the embryonic zebrafish brain
- Authors
- Wilson, S.W. and Easter, S.S. Jr.
- ID
- ZDB-PUB-961014-1264
- Date
- 1991
- Source
- Proceedings of the National Academy of Sciences of the United States of America 88(6): 2293-2296 (Journal)
- Registered Authors
- Easter, Stephen S., Jr., Wilson, Steve
- Keywords
- none
- MeSH Terms
-
- Animals
- Axons/ultrastructure*
- Brain/cytology
- Brain/embryology*
- Brain/ultrastructure
- Embryo, Nonmammalian
- Neurons/ultrastructure*
- Zebrafish/embryology*
- PubMed
- 2006169 Full text @ Proc. Natl. Acad. Sci. USA
Citation
Wilson, S.W. and Easter, S.S. Jr. (1991) A pioneering growth cone in the embryonic zebrafish brain. Proceedings of the National Academy of Sciences of the United States of America. 88(6):2293-2296.
Abstract
During development of the nervous system, growth cones navigate very precisely to their appropriate, often distant, targets. In insects, the task of establishing the earliest pathways is accomplished by a small number of neurons, termed pioneers. These neurons have axons that lay down an early scaffold, which provides a substrate for many later-developing axons. Here we show that a similar type of cell exists in the embryonic vertebrate brain. Using light- and electron-microscopic techniques we have examined the formation of one of the earliest tracts in the zebrafish brain. We find that it is pioneered at a precise time by the growth cone of a single neuron present in a predictable location. These observations show a fundamental similarity in the establishment of axonal pathways in the central nervous systems of both invertebrates and vertebrates.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping