ZFIN ID: ZDB-PUB-961014-1221
Gridlock, a localized heritable vascular patterning defect in the zebrafish
Weinstein, B.M., Stemple, D.L., Driever, W., and Fishman, M.C.
Date: 1995
Source: Nature medicine   1(11): 1143-1147 (Journal)
Registered Authors: Driever, Wolfgang, Fishman, Mark C., Stemple, Derek L., Weinstein, Brant M.
Keywords: none
MeSH Terms:
  • Angiography
  • Animals
  • Aorta/abnormalities*
  • Aorta/embryology
  • Aorta, Thoracic/embryology
  • Aortic Coarctation*/etiology
  • Aortic Coarctation*/genetics
  • Blood Circulation
  • Genes, Recessive
  • Humans
  • Mutation*
  • Zebrafish/embryology
  • Zebrafish/genetics*
PubMed: 7584985 Full text @ Nat. Med.
We are using the zebrafish, Danio rerio, to identify genes that generate and pattern the vertebrate vasculature. We have isolated a recessive mutation, gridlockm145 (grlm145) in which blood flow to the tail is impeded by a localized vascular defect. Using a novel microangiographic method, we show that the blockade is in the anterior trunk, where the paired lateral dorsal aortae normally merge to form the single midline aorta. Arterial-venous shunts and collateral vessels develop in most mutant embryos, bypassing the lesion and reconstituting caudal blood flow. The grl defect resembles coarctation of the aorta, a human congenital cardiovascular malformation of unknown aetiology, in the location of the lesion and its consequences and in the mutants' dependence on collateral vessels for survival.