ZFIN ID: ZDB-PUB-961014-1111
A homeobox gene essential for zebrafish notochord development
Talbot, W.S., Trevarrow, B., Halpern, M.E., Melby, A.E., Farr, G., Postlethwait, J.H., Jowett, T., Kimmel, C.B., and Kimelman, D.
Date: 1995
Source: Nature   378: 150-157 (Journal)
Registered Authors: Halpern, Marnie E., Jowett, Trevor, Kimelman, David, Kimmel, Charles B., Melby, Bess, Postlethwait, John H., Talbot, William S., Trevarrow, Bill
Keywords: none
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Differentiation/genetics
  • Chromosome Mapping
  • DNA Primers
  • DNA-Binding Proteins/genetics
  • Gastrula/cytology
  • Genes, Homeobox*
  • Genes, Lethal
  • Hedgehog Proteins
  • Homeodomain Proteins/genetics*
  • Humans
  • Mesoderm/cytology
  • Molecular Sequence Data
  • Motor Neurons/cytology
  • Mutation
  • Notochord/embryology*
  • Proteins/genetics
  • RNA, Messenger/biosynthesis
  • Stem Cells/cytology
  • Tail
  • Trans-Activators/genetics
  • Transcription Factors/genetics*
  • Xenopus Proteins*
  • Zebrafish
  • Zebrafish Proteins*
PubMed: 7477317 Full text @ Nature
The notochord is a midline mesodermal structure with an essential patterning function in all vertebrate embryos. Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate.