PUBLICATION
Analysis of a shark reveals ancient, Wnt-dependent, habenular asymmetries in vertebrates
- Authors
- Lanoizelet, M., Michel, L., Lagadec, R., Mayeur, H., Guichard, L., Logeux, V., Séverac, D., Martin, K., Klopp, C., Marcellini, S., Castillo, H., Pollet, N., Candal, E., Debiais-Thibaud, M., Boisvert, C., Billoud, B., Schubert, M., Blader, P., Mazan, S.
- ID
- ZDB-PUB-241127-11
- Date
- 2024
- Source
- Nature communications 15: 1019410194 (Journal)
- Registered Authors
- Blader, Patrick, Debiais-Thibaud, Mélanie, Schubert, Michael
- Keywords
- none
- MeSH Terms
-
- Wnt Signaling Pathway*
- Neurogenesis/genetics
- Sharks*/anatomy & histology
- Sharks*/embryology
- Sharks*/genetics
- Transcriptome
- Neurons/metabolism
- Wnt Proteins/genetics
- Wnt Proteins/metabolism
- Vertebrates/genetics
- Habenula*/metabolism
- Mice
- Gene Expression Regulation, Developmental
- Zebrafish*/genetics
- Biological Evolution
- Body Patterning/genetics
- Nodal Protein/genetics
- Nodal Protein/metabolism
- Animals
- PubMed
- 39587074 Full text @ Nat. Commun.
Citation
Lanoizelet, M., Michel, L., Lagadec, R., Mayeur, H., Guichard, L., Logeux, V., Séverac, D., Martin, K., Klopp, C., Marcellini, S., Castillo, H., Pollet, N., Candal, E., Debiais-Thibaud, M., Boisvert, C., Billoud, B., Schubert, M., Blader, P., Mazan, S. (2024) Analysis of a shark reveals ancient, Wnt-dependent, habenular asymmetries in vertebrates. Nature communications. 15:1019410194.
Abstract
The mode of evolution of left-right asymmetries in the vertebrate habenulae remains largely unknown. Using a transcriptomic approach, we show that in a cartilaginous fish, the catshark Scyliorhinus canicula, habenulae exhibit marked asymmetries, in both their medial and lateral components. Comparisons across vertebrates suggest that those identified in lateral habenulae reflect an ancestral gnathostome trait, partially conserved in lampreys, and independently lost in tetrapods and neopterygians. Asymmetry formation involves distinct mechanisms in the catshark lateral and medial habenulae. Medial habenulae are submitted to a marked, asymmetric temporal regulation of neurogenesis, undetectable in their lateral counterparts. Conversely, asymmetry formation in lateral habenulae results from asymmetric choices of neuronal identity in post-mitotic progenitors, a regulation dependent on the repression of Wnt signaling by Nodal on the left. Based on comparisons with the mouse and the zebrafish, we propose that habenular asymmetry formation involves a recurrent developmental logic across vertebrates, which relies on conserved, temporally regulated genetic programs sequentially shaping choices of neuronal identity on both sides and asymmetrically modified by Wnt activity.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping