PUBLICATION
Modelling 3D Tumour Microenvironment In Vivo: A Tool to Predict Cancer Fate
- Authors
- Marines, J., Lorenzini, F., Kissa, K., Fontenille, L.
- ID
- ZDB-PUB-231125-1
- Date
- 2023
- Source
- Current issues in molecular biology 45: 907690839076-9083 (Journal)
- Registered Authors
- Fontenille, Laura, Kissa-Marin, Karima
- Keywords
- PDX, cancer, live imaging, microenvironment, zebrafish
- MeSH Terms
- none
- PubMed
- 37998746 Full text @ Curr. Iss. Mol. Biol.
Citation
Marines, J., Lorenzini, F., Kissa, K., Fontenille, L. (2023) Modelling 3D Tumour Microenvironment In Vivo: A Tool to Predict Cancer Fate. Current issues in molecular biology. 45:907690839076-9083.
Abstract
Recently, many studies demonstrated the fundamental role of the tumour microenvironment (TME) in cancer progression. Here, we describe a method to visualize in 3D the behaviour of tumours in zebrafish embryos. We highlight two major actors of the TME, macrophages and vessels. This valuable tool is transposable to Patient-Derived Xenograft imaging in order to predict the fate of malignant tumours according to the dynamics of their TME.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping