PUBLICATION
Evaluation and Mechanistic Study of Transgenerational Neurotoxicity in Zebrafish upon Life Cycle Exposure to Decabromodiphenyl Ethane (DBDPE)
- Authors
- Sun, Y., Wang, X., Zhou, S., Zhou, Y., Hua, J., Guo, Y., Wang, Y., Zhang, W., Yang, L., Zhou, B.
- ID
- ZDB-PUB-231026-55
- Date
- 2023
- Source
- Environmental science & technology 57(44): 16811-16822 (Journal)
- Registered Authors
- Guo, YongYong, Yang, LiHua, Zhang, Wei, Zhou, BingSheng
- Keywords
- DNA methylation, cell cycle, decabromodiphenyl ethane, maternal factors, transgenerational neurotoxicity
- MeSH Terms
-
- Animals
- Bromobenzenes/toxicity
- Environmental Pollutants*
- Flame Retardants*/toxicity
- Humans
- Life Cycle Stages
- Zebrafish/genetics
- PubMed
- 37880149 Full text @ Env. Sci. Tech.
Citation
Sun, Y., Wang, X., Zhou, S., Zhou, Y., Hua, J., Guo, Y., Wang, Y., Zhang, W., Yang, L., Zhou, B. (2023) Evaluation and Mechanistic Study of Transgenerational Neurotoxicity in Zebrafish upon Life Cycle Exposure to Decabromodiphenyl Ethane (DBDPE). Environmental science & technology. 57(44):16811-16822.
Abstract
The novel brominated flame retardant decabromodiphenyl ethane (DBDPE) has become a ubiquitous emerging pollutant in the environment, which may evoke imperceptible effects in humans or wild animals. Hence in this study, zebrafish embryos were exposed to DBDPE (0, 0.1, 1, and 10 nM) until sexual maturity (F0), and F1 and F2 generations were cultured without further exposure to study the multi- and transgenerational toxicity and underlying mechanism. The growth showed sex-different changing profiles across three generations, and the social behavior confirmed transgenerational neurotoxicity in adult zebrafish upon life cycle exposure to DBDPE. Furthermore, maternal transfer of DBDPE was not detected, whereas parental transfer of neurotransmitters to zygotes was specifically disturbed in F1 and F2 offspring. A lack of changes in the F1 generation and opposite changing trends in the F0 and F2 generations were observed in a series of indicators for DNA damage, DNA methylation, and gene transcription. Taken together, life cycle exposure to DBDPE at environmentally relevant concentrations could induce transgenerational neurotoxicity in zebrafish. Our findings also highlighted potential impacts on wild gregarious fish, which would face higher risks from predators.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping