PUBLICATION
Exposure to valproic acid (VPA) reproduces hdac1 loss of function phenotypes in zebrafish
- Authors
- Jones, A.A., Willoner, T., Mishoe Hernandez, L., DeLaurier, A.
- ID
- ZDB-PUB-231013-64
- Date
- 2023
- Source
- microPublication. Biology 2023: (Journal)
- Registered Authors
- DeLaurier, April
- Keywords
- none
- MeSH Terms
- none
- PubMed
- 37829572 Full text @ MicroPubl Biol
Citation
Jones, A.A., Willoner, T., Mishoe Hernandez, L., DeLaurier, A. (2023) Exposure to valproic acid (VPA) reproduces hdac1 loss of function phenotypes in zebrafish. microPublication. Biology. 2023:.
Abstract
Histone deacetylases are enzymes that remove acetyl groups from histone tails and are understood to act as repressors of transcriptional activity. Hdac1 has been previously shown to function in eye, pectoral fin, heart, liver, and pharyngeal skeletal development. We show that high doses of Valproic Acid (VPA) reproduce the hdac1 phenotype. We identify tbx5 genes as potential targets of Hdac1 in eye, pectoral fin, and heart development. Using timed exposures, we show that skeletal structures in the pharyngeal arches are impacted by VPA between 24-36 hours post-fertilization, indicating a role for Hdac1 during post-migration patterning, differentiation, or proliferation of cranial neural crest cells.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping