PUBLICATION
kcnj13 regulates pigment cell shapes in zebrafish and diverged by cis-regulatory evolution between Danio species
- Authors
- Podobnik, M., Singh, A.P., Fu, Z., Dooley, C.M., Frohnhöfer, H.G., Firlej, M., Stednitz, S.J., Elhabashy, H., Weyand, S., Weir, J.R., Lu, J., Nüsslein-Volhard, C., Irion, U.
- ID
- ZDB-PUB-230803-36
- Date
- 2023
- Source
- Development (Cambridge, England) 150(16): (Journal)
- Registered Authors
- Dooley, Christopher, Frohnhöfer, Hans Georg, Irion, Uwe, Nüsslein-Volhard, Christiane, Podobnik, Marco
- Keywords
- Danio, Evolution, Pigment cell, Pigment pattern, Zebrafish
- MeSH Terms
-
- Animals
- Cell Shape
- Melanophores/physiology
- Pigmentation*/genetics
- Skin
- Zebrafish*/genetics
- PubMed
- 37530080 Full text @ Development
Citation
Podobnik, M., Singh, A.P., Fu, Z., Dooley, C.M., Frohnhöfer, H.G., Firlej, M., Stednitz, S.J., Elhabashy, H., Weyand, S., Weir, J.R., Lu, J., Nüsslein-Volhard, C., Irion, U. (2023) kcnj13 regulates pigment cell shapes in zebrafish and diverged by cis-regulatory evolution between Danio species. Development (Cambridge, England). 150(16):.
Abstract
Teleost fish of the genus Danio are excellent models to study the genetic and cellular bases of pigment pattern variation in vertebrates. The two sister species Danio rerio and Danio aesculapii show divergent patterns of horizontal stripes and vertical bars that are partly caused by the evolution of the potassium channel gene kcnj13. Here, we show that kcnj13 is required only in melanophores for interactions with xanthophores and iridophores, which cause location-specific pigment cell shapes and thereby influence colour pattern and contrast in D. rerio. Cis-regulatory rather than protein coding changes underlie kcnj13 evolution between the two Danio species. Our results suggest that homotypic and heterotypic interactions between the pigment cells and their shapes diverged between species by quantitative changes in kcnj13 expression during pigment pattern diversification.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping