PUBLICATION
Behavioral analysis through the lifespan of disc1 mutant zebrafish identifies defects in sensorimotor transformation
- Authors
- Pluimer, B.R., Harrison, D.L., Boonyavairoje, C., Prinssen, E.P., Rogers-Evans, M., Peterson, R.T., Thyme, S.B., Nath, A.K.
- ID
- ZDB-PUB-230707-39
- Date
- 2023
- Source
- iScience 26: 107099107099 (Journal)
- Registered Authors
- Nath, Anjali, Peterson, Randall, Thyme, Summer
- Keywords
- Behavior genetics, Behavioral neuroscience, Neuroscience
- MeSH Terms
- none
- PubMed
- 37416451 Full text @ iScience
Citation
Pluimer, B.R., Harrison, D.L., Boonyavairoje, C., Prinssen, E.P., Rogers-Evans, M., Peterson, R.T., Thyme, S.B., Nath, A.K. (2023) Behavioral analysis through the lifespan of disc1 mutant zebrafish identifies defects in sensorimotor transformation. iScience. 26:107099107099.
Abstract
DISC1 is a genetic risk factor for multiple psychiatric disorders. Compared to the dozens of murine Disc1 models, there is a paucity of zebrafish disc1 models-an organism amenable to high-throughput experimentation. We conducted the longitudinal neurobehavioral analysis of disc1 mutant zebrafish across key stages of life. During early developmental stages, disc1 mutants exhibited abrogated behavioral responses to sensory stimuli across multiple testing platforms. Moreover, during exposure to an acoustic sensory stimulus, loss of disc1 resulted in the abnormal activation of neurons in the pallium, cerebellum, and tectum-anatomical sites involved in the integration of sensory perception and motor control. In adulthood, disc1 mutants exhibited sexually dimorphic reduction in anxiogenic behavior in novel paradigms. Together, these findings implicate disc1 in sensorimotor processes and the genesis of anxiogenic behaviors, which could be exploited for the development of novel treatments in addition to investigating the biology of sensorimotor transformation in the context of disc1 deletion.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping