PUBLICATION
Circadian regulation of developmental synaptogenesis via the hypocretinergic system
- Authors
- Du, X.F., Li, F.N., Peng, X.L., Xu, B., Zhang, Y., Li, G., Liu, T., Li, Y., Wang, H., Yan, J., Du, J.L.
- ID
- ZDB-PUB-230604-37
- Date
- 2023
- Source
- Nature communications 14: 31953195 (Journal)
- Registered Authors
- Du, Jiu Lin, Liu, Taole, Peng, Xiao-Lan, Wang, Han
- Keywords
- none
- MeSH Terms
-
- Animals
- Axons
- Circadian Clocks*/physiology
- Circadian Rhythm/physiology
- Synapses/physiology
- Zebrafish*
- PubMed
- 37268623 Full text @ Nat. Commun.
Citation
Du, X.F., Li, F.N., Peng, X.L., Xu, B., Zhang, Y., Li, G., Liu, T., Li, Y., Wang, H., Yan, J., Du, J.L. (2023) Circadian regulation of developmental synaptogenesis via the hypocretinergic system. Nature communications. 14:31953195.
Abstract
The circadian clock orchestrates a wide variety of physiological and behavioral processes, enabling animals to adapt to daily environmental changes, particularly the day-night cycle. However, the circadian clock's role in the developmental processes remains unclear. Here, we employ the in vivo long-term time-lapse imaging of retinotectal synapses in the optic tectum of larval zebrafish and reveal that synaptogenesis, a fundamental developmental process for neural circuit formation, exhibits circadian rhythm. This rhythmicity arises primarily from the synapse formation rather than elimination and requires the hypocretinergic neural system. Disruption of this synaptogenic rhythm, by impairing either the circadian clock or the hypocretinergic system, affects the arrangement of the retinotectal synapses on axon arbors and the refinement of the postsynaptic tectal neuron's receptive field. Thus, our findings demonstrate that the developmental synaptogenesis is under hypocretin-dependent circadian regulation, suggesting an important role of the circadian clock in neural development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping