PUBLICATION
A New Hypoglycemic Prenylated Indole Alkaloid N-Oxide from Endophytic Fungus Pallidocercospora crystalline
- Authors
- Gao, S., Lin, X., Shi, Y., Zhou, H., Zheng, X., Li, M., Lin, T.
- ID
- ZDB-PUB-230528-51
- Date
- 2023
- Source
- International Journal of Molecular Sciences 24(10): (Journal)
- Registered Authors
- Li, Mingyu
- Keywords
- N-oxides, endophytic fungus, hypoglycemic activity, prenylated indole alkaloid, zebrafish
- MeSH Terms
-
- Alkaloids*/chemistry
- Animals
- Hypoglycemic Agents/pharmacology
- Indole Alkaloids/chemistry
- Molecular Structure
- Zebrafish*
- PubMed
- 37240113 Full text @ Int. J. Mol. Sci.
Citation
Gao, S., Lin, X., Shi, Y., Zhou, H., Zheng, X., Li, M., Lin, T. (2023) A New Hypoglycemic Prenylated Indole Alkaloid N-Oxide from Endophytic Fungus Pallidocercospora crystalline. International Journal of Molecular Sciences. 24(10):.
Abstract
A new prenylated indole alkaloid-Penicimutamide C N-oxide (1), a new alkaloid penicimutamine A (2), along with six known alkaloids were isolated from an endophytic fungus Pallidocercospora crystallina. A simple and accurate method was used to determine the N-O bond in the N-oxide group of 1. By using a β-cell ablation diabetic zebrafish model, compounds 1, 3, 5, 6 and 8 showed significantly hypoglycemic activities under the concentration of 10 μM. Further studies revealed that compounds 1 and 8 lowered the glucose level through promoting glucose uptake in zebrafish. In addition, all eight compounds showed no acute toxicity, teratogenicity, nor vascular toxicity in zebrafish under the concentrations range from 2.5 μΜ to 40 μM. Importantly, these results provide new lead compounds for the development of antidiabetes strategies.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping