PUBLICATION
The role of blood flow in vessel remodeling and its regulatory mechanism during developmental angiogenesis
- Authors
- Wen, L., Yan, W., Zhu, L., Tang, C., Wang, G.
- ID
- ZDB-PUB-230525-34
- Date
- 2023
- Source
- Cellular and molecular life sciences : CMLS 80: 162162 (Review)
- Registered Authors
- Wang, Guixue, Wen, Lin
- Keywords
- EC rearrangement, Hemodynamics, Vessel pruning, Wnt signaling, Zebrafish
- MeSH Terms
-
- Actin Cytoskeleton
- Animals
- Cardiovascular Physiological Phenomena
- Mechanotransduction, Cellular*
- Mice
- Vascular Endothelial Growth Factor A
- Zebrafish*
- PubMed
- 37221410 Full text @ Cell. Mol. Life Sci.
Citation
Wen, L., Yan, W., Zhu, L., Tang, C., Wang, G. (2023) The role of blood flow in vessel remodeling and its regulatory mechanism during developmental angiogenesis. Cellular and molecular life sciences : CMLS. 80:162162.
Abstract
Vessel remodeling is essential for a functional and mature vascular network. According to the difference in endothelial cell (EC) behavior, we classified vessel remodeling into vessel pruning, vessel regression and vessel fusion. Vessel remodeling has been proven in various organs and species, such as the brain vasculature, subintestinal veins (SIVs), and caudal vein (CV) in zebrafish and yolk sac vessels, retina, and hyaloid vessels in mice. ECs and periendothelial cells (such as pericytes and astrocytes) contribute to vessel remodeling. EC junction remodeling and actin cytoskeleton dynamic rearrangement are indispensable for vessel pruning. More importantly, blood flow has a vital role in vessel remodeling. In recent studies, several mechanosensors, such as integrins, platelet endothelial cell adhesion molecule-1 (PECAM-1)/vascular endothelial cell (VE-cadherin)/vascular endothelial growth factor receptor 2 (VEGFR2) complex, and notch1, have been shown to contribute to mechanotransduction and vessel remodeling. In this review, we highlight the current knowledge of vessel remodeling in mouse and zebrafish models. We further underline the contribution of cellular behavior and periendothelial cells to vessel remodeling. Finally, we discuss the mechanosensory complex in ECs and the molecular mechanisms responsible for vessel remodeling.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping