ZFIN Person: Wang, Guixue

ZFIN ID: ZDB-PERS-170214-19

ZFIN ID: ZDB-PERS-170214-19

Wang, Guixue

Email:	wanggx@cqu.edu.cn
URL:
Affiliation:	Wang GX Lab
Address:	Laboratory for Mechno-Developmental Biology, State and Local Joint Engineering Laboratory for Vascular Implants, College of Bioengineering, Chongqing University, 174 Shazhengjie, Shapingba, Chongqing, 400030, China,
Country:
Phone:	86-23-65112675
Fax:	86-23-65102507
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Zhang, T., Yan, W., Liu, C., Duan, W., Duan, Y., Li, Y., Yu, Q., Sun, Y., Tian, J., Zhou, J., Xia, Z., Wang, G., Xu, S. (2023) Cadmium exposure promotes ferroptosis by upregulating Heat Shock Protein 70 in vascular endothelial damage of zebrafish. Ecotoxicology and environmental safety. 263:115241115241

Wen, L., Yan, W., Zhu, L., Tang, C., Wang, G. (2023) The role of blood flow in vessel remodeling and its regulatory mechanism during developmental angiogenesis. Cellular and molecular life sciences : CMLS. 80:162162

Yan, Y., Liang, S., Zhang, T., Deng, C., Li, H., Zhang, D., Lei, D., Wang, G. (2023) Acute exposure of Isopyrazam damages the developed cardiovascular system of zebrafish (Danio rerio). Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 58(4):367-377

Cui, Y., Shi, W., Zhang, K., Hou, Z., Wang, Y., Yan, W., Ma, Q., He, S., Huang, J., Lu, C., Wang, Y., Wang, G., Qiu, J. (2022) Temporal-spatial low shear stress induces heterogenous distribution of hematopoietic stem cell budding in zebrafish. Cellular and molecular life sciences : CMLS. 79:399

Chen, G., Wang, M., Zhu, P., Wang, G., Hu, T. (2022) Adverse effects of SYP-3343 on zebrafish development via ROS-mediated mitochondrial dysfunction. Journal of hazardous materials. 437:129382

Liu, B., Yan, W., Luo, L., Wu, S., Wang, Y., Zhong, Y., Tang, D., Maruf, A., Yan, M., Zhang, K., Qin, X., Qu, K., Wu, W., Wang, G. (2021) Macrophage membrane camouflaged reactive oxygen species responsive nanomedicine for efficiently inhibiting the vascular intimal hyperplasia. Journal of nanobiotechnology. 19:374

Yu, L., He, M., Liu, S., Dou, X., Li, L., Gu, N., Li, B., Liu, Z., Wang, G., Fan, J. (2021) Fluorescent Egg White-Based Carbon Dots as a High-Sensitivity Iron Chelator for the Therapy of Nonalcoholic Fatty Liver Disease by Iron Overload in Zebrafish. ACS applied materials & interfaces. 13(46):54677-54689

Qin, X., Zhang, K., Qiu, J., Wang, N., Qu, K., Cui, Y., Huang, J., Luo, L., Zhong, Y., Tian, T., Wu, W., Wang, Y., Wang, G. (2021) Uptake of oxidative stress-mediated extracellular vesicles by vascular endothelial cells under low magnitude shear stress. Bioactive materials. 9:397-410

Lei, D., Zhang, X., Rouf, M.A., Mahendra, Y., Wen, L., Li, Y., Zhang, X., Li, L., Wang, L., Zhang, T., Wang, G., Wang, Y. (2021) Noncanonical protease-activated receptor 1 regulates lymphatic differentiation in zebrafish. iScience. 24:103386

Zhong, Y., Qin, X., Wang, Y., Qu, K., Luo, L., Zhang, K., Liu, B., Obaid, E.A.M.S., Wu, W., Wang, G. (2021) "Plug and Play" Functionalized Erythrocyte Nanoplatform for Target Atherosclerosis Management. ACS applied materials & interfaces. 13:33862-33873

Wen, L., Zhang, T., Wang, J., Jin, X., Rouf, M.A., Luo, D., Zhu, Y., Lei, D., Gregersen, H., Wang, Y., Wang, G. (2021) The blood flow-klf6a-tagln2 axis drives vessel pruning in zebrafish by regulating endothelial cell rearrangement and actin cytoskeleton dynamics. PLoS Genetics. 17:e1009690

Wang, Q., Chen, G., Zhang, Q., Wang, M., Wang, G., Hu, T. (2021) Microcystin-leucine arginine blocks vasculogenesis and angiogenesis through impairing cytoskeleton and impeding endothelial cell migration by downregulating integrin-mediated Rho/ROCK signaling pathway. Environmental science and pollution research international. 28(47):67108-67119

Zhang, T., Xu, Z., Wen, L., Lei, D., Li, S., Wang, J., Huang, J., Wang, N., Durkan, C., Liao, X., Wang, G. (2021) Cadmium-induced dysfunction of the blood-brain barrier depends on ROS-mediated inhibition of PTPase activity in zebrafish. Journal of hazardous materials. 412:125198

Ge, S., Xi, Y., Du, R., Ren, Y., Xu, Z., Tan, Y., Wang, Y., Yin, T., Wang, G. (2019) Inhibition of in-stent restenosis after graphene oxide double-layer drug coating with good biocompatibility. Regenerative biomaterials. 6:299-309

Huang, L., Tjakra, M., Luo, D., Wen, L., Lei, D., Wang, J., Yin, T., Zhang, X., Huang, J., Wang, Y., Wang, G. (2019) FoxF1 is Required for Ciliogenesis and Distribution of Sonic Hedgehog Signaling Components in Cilium. Current Molecular Medicine. 19(5):326-334

Xie, X., Lei, D., Zhang, Q., Wang, Y., Wen, L., Ye, Z., Ud Din, A., Jia, D., Apicella, A., Wang, G. (2019) Effect of simulated microgravity induced PI3K-nos2b signalling on zebrafish cardiovascular plexus network formation. Journal of biomechanics. 87:83-92

Wang, Q., Liu, Y., Guo, J., Lin, S., Wang, Y., Yin, T., Gregersen, H., Hu, T., Wang, G. (2018) Microcystin-LR induces angiodysplasia and vascular dysfunction through promoting cell apoptosis by the mitochondrial signaling pathway. Chemosphere. 218:438-448

Luo, L., Wu, W., Sun, D., Dai, H.B., Wang, Y., Zhong, Y., Wang, J.X., Maruf, A., Nurhidayah, D., Zhang, X.J., Wang, Y., Wang, G.X. (2018) Acid-Activated Melittin for Targeted and Safe Antitumor Therapy. Bioconjugate Chemistry. 29:2936-2944

Xie, X., Zhou, T., Wang, Y., Chen, H., Lei, D., Huang, L., Wang, Y., Jin, X., Sun, T., Tan, J., Yin, T., Huang, J., Gregersen, H., Wang, G. (2018) Blood Flow Regulates Zebrafish Caudal Vein Plexus Angiogenesis by ERK5-klf2a-nos2b Signaling. Current Molecular Medicine. 18(1):3-14

Chen, J., Wu, Q., Luo, L., Wang, Y., Zhong, Y., Dai, H.B., Sun, D., Luo, M.L., Wu, W., Wang, G.X. (2017) Dual tumor-targeted poly(lactic-co-glycolic acid)-polyethylene glycol-folic acid nanoparticles: a novel biodegradable nanocarrier for secure and efficient antitumor drug delivery.. International Journal of Nanomedicine. 12:5745-5760

Zou, D., Wang, W., Lei, D., Yin, Y., Ren, P., Chen, J., Yin, T., Wang, B., Wang, G., Wang, Y. (2017) Penetration of blood-brain barrier and antitumor activity and nerve repair in glioma by doxorubicin-loaded monosialoganglioside micelles system. International Journal of Nanomedicine. 12:4879-4889

Zhou, T., Dong, Q., Shen, Y., Wu, W., Wu, H., Luo, X., Liao, X., Wang, G. (2016) PEG-b-PCL polymeric nano-micelle inhibits vascular angiogenesis by activating p53-dependent apoptosis in zebrafish.. International Journal of Nanomedicine. 11:6517-6531

Xie, X., Lei, D., Liu, Y., Huang, L., Zhou, T., Wang, Y., Wang, G. (2015) S22 is required in the process of blood flow regulate the vascular development in zebrafish. Biorheology. 52(1-2):112

Sun, T., Xie, X., Zhang, J.Q., Bao, J., Tang, C.Z., Lei, D.X., Qiu, J.H., and Wang, G.X. (2013) Effect of horizontal rotary culture on zebrafish vascular development. Yi chuan = Hereditas. 35(4):502-510

Xie, X., Tan, J., Wei, D., Lei, D., Yin, T., Huang, J., Zhang, X., Qiu, J., Tang, C., and Wang, G. (2013) In vitro and in vivo investigations on the effects of low-density lipoprotein concentration polarization and haemodynamics on atherosclerotic localization in rabbit and zebrafish. Journal of the Royal Society, Interface. 10(82):20121053

Tan, J., Wang, G.X., Xie, X., Tang, C.J., Qiu, J.H., Luo, L.F. (2010) Model establishment of lipoprotein accumulation observation in vivo in zebrafish. Hypertension (Dallas, Tex. : 1979). 56(6):1180

Wang, Y., Kaiser, M.S., Larson, J.D., Nasevicius, A., Clark, K.J., Wadman, S.A., Roberg-Perez, S.E., Ekker, S.C., Hackett, P.B., McGrail, M., and Essner, J.J. (2010) Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis. Development (Cambridge, England). 137(18):3119-3128

NON-ZEBRAFISH PUBLICATIONS
M H Li, H D Wu, Y Wang, T Y Yin, H Gregersen, X J Zhang, X L Liao, G X Wang. Immobilization of heparin/poly-l-lysine microspheres on medical grade high nitrogen nickel-free austenitic stainless steel surface to improve the biocompatibility and suppress thrombosis. Mat Sci Eng C-Mater. 2017, 73: 198-205.
H B Jiang, D H Liao, J B Zhao, G X Wang, H Gregersen. Reversible stress softening in layered rat esophagus in vitro after potassium chloride activation. Biomech Model Mechan. 2017, doi: 10.1007/s10237-017-0873-y.
C J Tang, Y Y Wang, D X Lei, L Huang, G X Wang, Q J Chi, Y M Zheng, C Gachet, P H Mangin, L Zhu. Standardization of a well-controlled in vivo mouse model of thrombus formation induced by mechanical injury. Thromb Res. 2016, 141: 49-57.
L Huang, D X Lei, W X Dong, C J Tang, G X Wang. Thrombosis model in mouse carotid induced by guidewire. J Med Biol Eng. 2016, 6(2): 236-244.
Y Wang, J H Qiu, S S Luo, X Xie, Y M Zheng, K Zhang, Z Y Ye, W Q Liu, H Gregersen, G X Wang. High shear stress induces atherosclerotic vulnerable plaque formation through angiogenesis. Regenerative Biomaterials. 2016, 257–267.
D Sun, D K Xu, C G Yang, M B Shahzad, Z Q Sun, J Xia, J L Zhao, T Y Gu, K Yang, G X Wang. An investigation of the antibacterial ability and cytotoxicity of a novel cu-bearing 317L stainless steel. Scientific Reports. 2016, 6: 29244.
D Sun, D K Xu, C G Yang, J Chen, M B Shahzad, Z Q Sun, J L Zhao, T Y Gu, K Yang, G X Wang. Inhibition of Staphylococcus aureus biofilm by a copper-bearing 317L-Cu stainless steel and its corrosion resistance. Mat Sci Eng C-Mater. 2016, 69: 744-750.
J J Hu, J H Qiu, Y M Zheng, T Zhang, T Y Yin, X Xie, G X Wang. AAMP regulates endothelial cell migration and angiogenesis through RhoA/Rho kinase signaling. Ann Biomed Eng. 2016, 44(5): 1462–1474.
G C Zang, Hanyan Zou, Y C Zhang, Z Xiang, J L Huang, L Luo, C P Wang, K R Lei, X Y Li, D M Song, A U Din, G X Wang. The De-Etiolated 1 homolog of arabidopsis modulates the ABA signaling pathway and ABA biosynthesis in rice. Plant Physiol. 2016, 171: 1259–1276.
X Wu, Y P Zhao, C J Tang, T Y Yin, R L Du, J Tian, J L Huang, H Gregersen, G X Wang. Re-endothelialization study on endovascular stents seeded by endothelial cells through up- or down-regulation of VEGF. ACS Appl Mater Interfaces. 2016, 8(11): 7578-7589.
H L Lan, Y Wang, T Y Yin, Y Z Wang, W Q Liu, X J Zhang, Q S Yu, Z X Wang, G X Wang. Progress and prospects of endothelial progenitor cell therapy in coronary stent implantation: progress and prospects of EPC therapy. J Biomed Mater Res B. 2016, 104(6): 1237-1247.
T Z Hu, J L Yang, K Cui, Q Rao, T Y Yin, L L Tan, Y Zhang, Z G Li, G X Wang. Controlled slow-release drug-eluting stents for the prevention of coronary restenosis: recent progress and future prospects. ACS Applied Materials Interfaces. 2015, 7(22): 11695-11712.
S P Ge, Y Wang, J Tian, D X Lei, Q S Yu, G X Wang. An in vitro study on the biocompatibility of WE magnesium alloys. J Biomed Mater Res B. 2015, 8: 2190-2198.
Q Zhang, Y Shen, C J Tang, X Wu, Q S Yu, G X Wang. Surface modification of stent with SiCOH coating for improvement of anticoagulation and endothelialization. J Biomed Mater Res B. 2015, 103B: 464-472.
X Wu, T Y Yin, J Tian, C J Tang, J L Huang, Y P Zhao, X J Zhang, X Y Deng, Y B Fan, D H Yu, G X Wang. Distinctive effects of CD34- and CD133-specific antibody-coated stents on re-endothelialization and in-stent restenosis at the early phase of vascular injury. Regenative Biomaterials. 2015, (2): 87–96.
T Zhou, Q L Dong, Y Shen, S P Ge, Q Zhang, X L Luo, G X Wang. Biological effects of gold nanoparticles modified by self-assembled monolayers (in Chinese). Rare Metal Mat and Eng. 2015, 44(5): 1203-1206.
H Y Zou, Y H Wenwen, G C Zang, Z H Kang, J L Huang, G X Wang. OsEXPB2, a beta-expansin gene, is involved in rice root system architecture. Mol Breeding. 2015, 35(1): 1380-3743.
Y Shen, M Gao, Y L Ma, H C Yu, Xi H Liu, G X Wang. Effect of surface chemistry on the integrin induced pathway in regulating vascular endothelial cells migration. Colloids and Surfaces B-Biointerfaces. 2015, 126: 0927-7765.
Y Shen, M T Leng, H C Yu, Q Zhang, X L Luo, H Gregersen, G X Wang, X H Liu. Effect of amphiphilic PCL–PEG nano-micelles on HepG2 cell migration. Macromol Biosci. 2015, 15: 372–384.
D M Sun,Y M Zheng, T Y Yin, C J Tang, Q S Yu, G X Wang. Coronary drug-eluting stents: from design optimization to newer strategies. J Biomed Mater Res Part A. 2014,102A:1625–1640.
T Zhou, Y M Zheng, J H Qiu, J J Hu, D M Sun, C J Tang, G X Wang. Endothelial mechanotransduction mechanism in atherosclerosis. J Mech Med Biol. 2014, 14(5): 1430006.
Q J Chi, T Y Yin, H Gregersen, G X Wang. Rear actomyosin contractility-driven directional cell migration in three-dimensional matrices: a mechanochemical coupling mechanism. J R Soc Interface. 2014, 11(95): 1742-5689.
H B Jiang, G X Wang, H Gregersen. Contractions Reverse Stress Softening in Rat Esophagus. Ann Biomed Eng. 2014, 42(8): 0090-6964.
T Z Hu, Y W Yang, L L Tan, G X Wang. Effects of gamma irradiation and moist heat for sterilization on sodium alginate. Bio-Med Mater Eng. 2014, 24(5): 1837-1849.
P Zhang, Y P Chen, J S Guo, Y Shen, J X Yang, F Fang, C Li, X Gao, G X Wang. Adsorption behavior of tightly bound extracellular polymeric substances on model organic surfaces under different pH and cations with surface plasmon resonance. Water Res. 2014, 57(12): 31-39.
Q J Chi, T Y Yin, H Gregersen, X Y Deng, Y B Fan, J B Zhao, D HLiao, G X Wang. Rear actomyosin contractility-driven directional cell migration in three-dimensional matrices: a mechano-chemical coupling mechanism. J R Soc Interface. 2014, 11(95): 20131072(10 pages).
J H Qiu, Y M Zheng, J J Hu, D H Liao，H Gregersen, X Y Deng, Y B Fan, G X Wang. Biomechanical regulation of vascular smooth muscle cell functions: from in vitro to in vivo understanding. J R Soc Interface. 2014, 11: 20130852.
Y Q Teng, J H Qiu, Y M Zheng, X D Luo, L L Zhang, L Chen, G X Wang. Effects of type I collagen and fibronectin on regulation of breast cancer cell biological and biomechanical characteristics. J Med Biol Eng. 2014, 34(1): 62-68.
F Guo, X Li, J Peng, Y Tang, Q Yang, L Liu, Z Wang, Z Jiang, M Xiao, C Ni, R Chen, D Wei, G X Wang. Autophagy Regulates Vascular Endothelial Cell eNOS and ET-1 Expression Induced by Laminar Shear Stress in an Ex Vivo Perfused System. Ann Biomed Eng. 2014, 42(9): 1978-1988.
Q Wu, Z H Tang, J Peng, L Liao, L H Pan, C Y Wu, Z S Jiang, G X Wang, L S Liu. The dual behavior of PCSK9 in the regulation of apoptosis is crucial in Alzheimer's disease progression (Review). Biomed Rep. 2014, 2(2): 167-171.
S C Sheng, X M Lu, Y Kang, Y P Du, G X Wang. High sensitivity cardiac troponin T is a predictor of reoccurrence on acute coronary syndrome for patients with acute myocardial infarction. Genet Mol Res. 2014, 13(2): 3819-3825.
D H Wei, X L Zhang, R Wang, J K Zhang, J Yang, S Li, X L Lin, Z S Jiang, G X Wang, Z Wang. Oxidized Lipoprotein(a) increases endothelial cell monolayer permeability via ROS generation. Lipids. 2013, 48: 579–586.
D H Wei, Y P Chen, C J Tang, H Huang, L S Liu, Z Wang, R M Li, G X Wang. Low density lipoprotein decreases the membrane compliance and cell adhesion of endothelial cells under fluid shear stress. Ann Biomed Eng. 2013, 41: 611-618.
H G Wang, T Y Yin, S P Ge, Q Zhang, Q L Dong, D X Lei, D M Sun, G X Wang. Biofunctionalization of titanium surface with multilayer film modified by heparin-VEGF-fibronectin complex to improve endothelial cell proliferation and blood compatibility. J Biomed Mater Res A. 2013, 101(2): 413-420.
Y M Zheng, J H Qiu, J J Hu, G X Wang. Concepts and hypothesis: Integrin Cytoplasmic Domain-Associated Protein-1 (ICAP-1) as a potential player in cerebral cavernous malformation. J Neurol. 2013, 260: 10–19.
J H Qiu, Q Peng, Y M Zheng, J J Hu, X D Luo, Y Q Teng, J Tao, T Y Yin, C J Tang, G X Wang. OxLDL stimulates Id1 nucleocytoplasmic shuttling in endothelial cell angiogenesis via PI3K pathway. BBA-Mol Cell Biol L. 2012, 1821(10): 1361-1369.
D H Wei, G X Wang, C J Tang, J H Qiu, J B Zhao, H Gregersen, L H Deng. Upregulation of SDF-1 is associated with atherosclerosis lesions induced by LDL concentration polarization. Ann Biomed Eng. 2012, 40(5): 1018-1027.
Y Shen, G X Wang, X L Huang, Q Zhang, J Wu, C J Tang, Q S Yu, X H Liu. Surface wettability of plasma SiOx:H nanocoating-induced endothelial cells migration and the associated FAK-Rho GTPases signalling pathways. J R Soc Interface. 2012, 9(67): 313–327.
B Ling, G X Wang, G Long, J H Qiu, Z L Hu. Tumor suppressor miR-22 suppresses lung cancer cell progression through post-transcriptional regulation of ErbB3. J Cancer Res Clin. 2012, 138(8): 1355-1361.
G X Wang, H L Chen, H Y Jiang, T Y Yin, L Y Wu. Effect of sophora flavescens alkaloids on the proliferation and migration of vascular smooth muscle cells and endothelial cells. J Med Biol Eng. 2012, 32(3): 195-199.
H Huang, L Q Ye, C J Tang, T Sun, G X Wang. Impacts of Low Density Lipoprotein on Adhesive Mechanical Properties of Endothelial Cells and Collagen IV. Biomed Eng-App Bas C. 2012, 24(1): 1-7.
T Y Yin, G X Wang, D C Zhang, D Y Du, Z G Li, L L Luo, Y B Hou, Y Z Wang, J B Zhao, H Gregersen. Endothelialization and in-stent restenosis on the surface of glycoprotein IIIa monoclonal antibody eluting stent. J Biomed Mater A. 2012, 100(6): 1398-1406.
G X Wang, L Xiao, X Wu, X Xie, C J Tang, L Yang, J C M. Lee. Effects of different adhesive substrates on the adherent forcesof endothelial progenitor cells. J Med Biol Eng. 2012, 32(1): 70-76.
C J Tang,G X Wang, X Wu, Z G Li, Y Shen, J C M. Lee, Q S Yu.The impact of VEGF-transfected human endothelial cells on endothelialization and restenosis of stainless steel stents. J Vasc Surg. 2011, 53: 461-471.
L L Luo, G X Wang, Y L Li, T Y Yin, T Jiang, C G Ruan. Layer-by-layer assembly of chitosan and platelet monoclonal antibody to improve biocompatibility and release character of PLLA coated stent. J Biomed Mater Res A. 2011, 97A(4): 423-432.
L Y Wu, G X Wang, P Qu, C Yan, H Du. Overexpression of dominant negative Peroxisome Proliferator-Activated Receptor-(PPAR) in alveolar type II epithelial cells causes inflammation and T-Cell suppression in the lung. Am J Pathol. 2011, 178(5): 2191–2204.
J H Qiu, G X Wang, J J Hu, Q Peng, Y M Zheng. Id1-induced inhibition of p53 facilitates endothelial cell migration and tube formation by regulating the expression of beta1-integrin. Mol Cell Biochem. 2011, 357: 125-133.
J H Qiu,G X Wang, Q Peng, J J Hu, X D Luo,Y M Zheng, Y Q Teng, C J Tang. Id1 induces tubulogenesis by regulating endothelial cell adhesion and cytoskeletal organization through beta1-integrin and Rho-kinase signaling. Journal of Molecular Medicine. 2011, 28(4): 543-548.
J H Qiu, G X Wang, Y M Zheng, J J Hu, Q Peng, T Y Yin. Coordination of Id1 and p53 activation by oxidised LDL regulates endothelial cell proliferation and migration. An Biome Eng. 2011, 39(12): 2869-2878.
C J Tang, G X Wang, Y Shen, L J Wan, L Xiao, Q Zhang, Q S Yu, L S Liu, G B Wen. A study on surface endothelialization of plasma coated intravascular stents. Surf Coat Technol. 2010, 204(9-10):1487-149.
Y Shen, G X Wang, Q Zhang, C J Tang, S P Ge, Q S Yu. Effects of micropatterned surface of NiTi alloy on adhesion of endothelial cells and blood platelets (in Chinese). Rare Metal Mat Eng. 2010, 39(6): 1018-1022.
Y Shen , G X Wang, L Chen, H Li, P Yu, M J Bai, Q Zhang, J Lee, Q S Yu. Investigation of surface endothelialization on biomedical nitinol (NiTi) alloy: Effects of surface micropatterning combined with plasma nanocoatings. Acta Biomater. 2009, 5(9): 3593-360.
T Jiang, G X Wang, J H Qiu, L L Luo, G Q Zhang. Preparation and Biocompatibility of Polyvinyl alcohol – Small Intestinal Submucosa Hydrogel Membranes. J Med Biol Eng. 2009, 29(2): 102-107.