PUBLICATION
Mesenchymal Stromal Cells Facilitate Tip Cell Fusion Downstream of BMP (Bone Morphogenic Protein)-Mediated Venous Angiogenesis
- Authors
- Eisa-Beygi, S., Hu, M.M., Kumar, S.N., Jeffery, B.E., Collery, R.F., Vo, N.J., Lamichanne, B.S., Yost, H.J., Veldman, M.B., Link, B.A.
- ID
- ZDB-PUB-230502-46
- Date
- 2023
- Source
- Arteriosclerosis, Thrombosis, and Vascular Biology 43(7): e231-e237 (Journal)
- Registered Authors
- Collery, Ross, Eisa-Beygi, Shahram, Link, Brian, Yost, H. Joseph
- Keywords
- anastomosis, angiogenesis, arteriovenous development, mesenchymal stromal cells, zebrafish
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Bone Morphogenetic Proteins*/genetics
- Bone Morphogenetic Proteins*/metabolism
- Cell Communication
- Cell Fusion
- Mesenchymal Stem Cells*/metabolism
- Stromal Cells/metabolism
- PubMed
- 37128914 Full text @ Arterio., Thromb., and Vas. Bio.
Citation
Eisa-Beygi, S., Hu, M.M., Kumar, S.N., Jeffery, B.E., Collery, R.F., Vo, N.J., Lamichanne, B.S., Yost, H.J., Veldman, M.B., Link, B.A. (2023) Mesenchymal Stromal Cells Facilitate Tip Cell Fusion Downstream of BMP (Bone Morphogenic Protein)-Mediated Venous Angiogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology. 43(7):e231-e237.
Abstract
Background The goal of this study was to identify and characterize cell-cell interactions that facilitate endothelial tip cell fusion downstream of BMP (bone morphogenic protein)-mediated venous plexus formation.
Methods High resolution and time-lapse imaging of transgenic reporter lines and loss-of-function studies were carried out to study the involvement of mesenchymal stromal cells during venous angiogenesis.
Results BMP-responsive stromal cells facilitate timely and precise fusion of venous tip cells during developmental angiogenesis.
Conclusions Stromal cells are required for anastomosis of venous tip cells in the embryonic caudal hematopoietic tissue.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping