PUBLICATION
Prolonged Piezo1 Activation Induces Cardiac Arrhythmia
- Authors
- Rolland, L., Torrente, A.G., Bourinet, E., Maskini, D., Drouard, A., Chevalier, P., Jopling, C., Faucherre, A.
- ID
- ZDB-PUB-230414-55
- Date
- 2023
- Source
- International Journal of Molecular Sciences 24(7): (Journal)
- Registered Authors
- Faucherre, Adele, Jopling, Chris
- Keywords
- PIEZO1 channel, cardiac arrhythmia, mechanoelectric feedback
- MeSH Terms
-
- Animals
- Arrhythmias, Cardiac*/genetics
- Cardiac Conduction System Disease
- Humans
- Ion Channels*/genetics
- Ion Channels*/metabolism
- Mechanotransduction, Cellular/physiology
- Myocytes, Cardiac/metabolism
- Zebrafish/metabolism
- Zebrafish Proteins/genetics
- PubMed
- 37047693 Full text @ Int. J. Mol. Sci.
Citation
Rolland, L., Torrente, A.G., Bourinet, E., Maskini, D., Drouard, A., Chevalier, P., Jopling, C., Faucherre, A. (2023) Prolonged Piezo1 Activation Induces Cardiac Arrhythmia. International Journal of Molecular Sciences. 24(7):.
Abstract
The rhythmical nature of the cardiovascular system constantly generates dynamic mechanical forces. At the centre of this system is the heart, which must detect these changes and adjust its performance accordingly. Mechanoelectric feedback provides a rapid mechanism for detecting even subtle changes in the mechanical environment and transducing these signals into electrical responses, which can adjust a variety of cardiac parameters such as heart rate and contractility. However, pathological conditions can disrupt this intricate mechanosensory system and manifest as potentially life-threatening cardiac arrhythmias. Mechanosensitive ion channels are thought to be the main proponents of mechanoelectric feedback as they provide a rapid response to mechanical stimulation and can directly affect cardiac electrical activity. Here, we demonstrate that the mechanosensitive ion channel PIEZO1 is expressed in zebrafish cardiomyocytes. Furthermore, chemically prolonging PIEZO1 activation in zebrafish results in cardiac arrhythmias. indicating that this ion channel plays an important role in mechanoelectric feedback. This also raises the possibility that PIEZO1 gain of function mutations could be linked to heritable cardiac arrhythmias in humans.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping