PUBLICATION
Neuronal birthdate reveals topography in a vestibular brainstem circuit for gaze stabilization
- Authors
- Goldblatt, D., Huang, S., Greaney, M.R., Hamling, K.R., Voleti, V., Perez-Campos, C., Patel, K.B., Li, W., Hillman, E.M.C., Bagnall, M.W., Schoppik, D.
- ID
- ZDB-PUB-230317-46
- Date
- 2023
- Source
- Current biology : CB 33(7): 1265-1281.e7 (Journal)
- Registered Authors
- Bagnall, Martha, Schoppik, David
- Keywords
- circuit assembly, development, topography, vestibular, zebrafish
- MeSH Terms
-
- Animals
- Brain Stem
- Neurons*/physiology
- Reflex, Vestibulo-Ocular/physiology
- Vestibular Nuclei/physiology
- Zebrafish*/physiology
- PubMed
- 36924768 Full text @ Curr. Biol.
Citation
Goldblatt, D., Huang, S., Greaney, M.R., Hamling, K.R., Voleti, V., Perez-Campos, C., Patel, K.B., Li, W., Hillman, E.M.C., Bagnall, M.W., Schoppik, D. (2023) Neuronal birthdate reveals topography in a vestibular brainstem circuit for gaze stabilization. Current biology : CB. 33(7):1265-1281.e7.
Abstract
Across the nervous system, neurons with similar attributes are topographically organized. This topography reflects developmental pressures. Oddly, vestibular (balance) nuclei are thought to be disorganized. By measuring activity in birthdated neurons, we revealed a functional map within the central vestibular projection nucleus that stabilizes gaze in the larval zebrafish. We first discovered that both somatic position and stimulus selectivity follow projection neuron birthdate. Next, with electron microscopy and loss-of-function assays, we found that patterns of peripheral innervation to projection neurons were similarly organized by birthdate. Finally, birthdate revealed spatial patterns of axonal arborization and synapse formation to projection neuron outputs. Collectively, we find that development reveals previously hidden organization to the input, processing, and output layers of a highly conserved vertebrate sensorimotor circuit. The spatial and temporal attributes we uncover constrain the developmental mechanisms that may specify the fate, function, and organization of vestibulo-ocular reflex neurons. More broadly, our data suggest that, like invertebrates, temporal mechanisms may assemble vertebrate sensorimotor architecture.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping