PUBLICATION
Teneurin trans-axonal signaling prunes topographically missorted axons
- Authors
- Spead, O., Moreland, T., Weaver, C.J., Costa, I.D., Hegarty, B., Kramer, K.L., Poulain, F.E.
- ID
- ZDB-PUB-230302-34
- Date
- 2023
- Source
- Cell Reports 42: 112192112192 (Journal)
- Registered Authors
- Kramer, Kenneth, Poulain, Fabienne
- Keywords
- CP: Neuroscience, axon signaling, axon-axon interactions, degeneration, heparan sulfate, pre-target axon sorting, refinement, zebrafish
- MeSH Terms
-
- Axons/metabolism
- Glypicans*/metabolism
- Retina/physiology
- Retinal Ganglion Cells/metabolism
- Visual Pathways*/physiology
- PubMed
- 36857189 Full text @ Cell Rep.
Citation
Spead, O., Moreland, T., Weaver, C.J., Costa, I.D., Hegarty, B., Kramer, K.L., Poulain, F.E. (2023) Teneurin trans-axonal signaling prunes topographically missorted axons. Cell Reports. 42:112192112192.
Abstract
Building precise neural circuits necessitates the elimination of axonal projections that have inaccurately formed during development. Although axonal pruning is a selective process, how it is initiated and controlled in vivo remains unclear. Here, we show that trans-axonal signaling mediated by the cell surface molecules Glypican-3, Teneurin-3, and Latrophilin-3 prunes misrouted retinal axons in the visual system. Retinotopic neuron transplantations revealed that pioneer ventral axons that elongate first along the optic tract instruct the pruning of dorsal axons that missort in that region. Glypican-3 and Teneurin-3 are both selectively expressed by ventral retinal ganglion cells and cooperate for correcting missorted dorsal axons. The adhesion G-protein-coupled receptor Latrophilin-3 signals along dorsal axons to initiate the elimination of topographic sorting errors. Altogether, our findings show an essential function for Glypican-3, Teneurin-3, and Latrophilin-3 in topographic tract organization and demonstrate that axonal pruning can be initiated by signaling among axons themselves.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping