PUBLICATION
Molecular Actors of Inflammation and Their Signaling Pathways: Mechanistic Insights from Zebrafish
- Authors
- Leiba, J., Özbilgiç, R., Hernández, L., Demou, M., Lutfalla, G., Yatime, L., Nguyen-Chi, M.
- ID
- ZDB-PUB-230226-37
- Date
- 2023
- Source
- Biology 12(2): (Review)
- Registered Authors
- Lutfalla, Georges, Yatime, Laure
- Keywords
- cell signaling, inflammation, innate immunity, molecular mechanisms, zebrafish
- MeSH Terms
- none
- PubMed
- 36829432 Full text @ Biology (Basel)
Citation
Leiba, J., Özbilgiç, R., Hernández, L., Demou, M., Lutfalla, G., Yatime, L., Nguyen-Chi, M. (2023) Molecular Actors of Inflammation and Their Signaling Pathways: Mechanistic Insights from Zebrafish. Biology. 12(2):.
Abstract
Inflammation is a hallmark of the physiological response to aggressions. It is orchestrated by a plethora of molecules that detect the danger, signal intracellularly, and activate immune mechanisms to fight the threat. Understanding these processes at a level that allows to modulate their fate in a pathological context strongly relies on in vivo studies, as these can capture the complexity of the whole process and integrate the intricate interplay between the cellular and molecular actors of inflammation. Over the years, zebrafish has proven to be a well-recognized model to study immune responses linked to human physiopathology. We here provide a systematic review of the molecular effectors of inflammation known in this vertebrate and recapitulate their modes of action, as inferred from sterile or infection-based inflammatory models. We present a comprehensive analysis of their sequence, expression, and tissue distribution and summarize the tools that have been developed to study their function. We further highlight how these tools helped gain insights into the mechanisms of immune cell activation, induction, or resolution of inflammation, by uncovering downstream receptors and signaling pathways. These progresses pave the way for more refined models of inflammation, mimicking human diseases and enabling drug development using zebrafish models.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping