PUBLICATION
The Contribution of the Zebrafish Model to the Understanding of Polycomb Repression in Vertebrates
- Authors
- Hanot, M., Raby, L., Völkel, P., Le Bourhis, X., Angrand, P.O.
- ID
- ZDB-PUB-230212-33
- Date
- 2023
- Source
- International Journal of Molecular Sciences 24(3): (Review)
- Registered Authors
- Angrand, Pierre-Olivier, Raby, Ludivine, Völkel, Pamela
- Keywords
- PRC1, PRC2, epigenetics, gene editing, morpholino, zebrafish
- MeSH Terms
-
- Animals
- Drosophila Proteins*/metabolism
- Epigenesis, Genetic
- Humans
- Polycomb Repressive Complex 1/metabolism
- Polycomb-Group Proteins/genetics
- Polycomb-Group Proteins/metabolism
- Zebrafish*/genetics
- Zebrafish*/metabolism
- PubMed
- 36768643 Full text @ Int. J. Mol. Sci.
Citation
Hanot, M., Raby, L., Völkel, P., Le Bourhis, X., Angrand, P.O. (2023) The Contribution of the Zebrafish Model to the Understanding of Polycomb Repression in Vertebrates. International Journal of Molecular Sciences. 24(3):.
Abstract
Polycomb group (PcG) proteins are highly conserved proteins assembled into two major types of complexes, PRC1 and PRC2, involved in the epigenetic silencing of a wide range of gene expression programs regulating cell fate and tissue development. The crucial role of PRC1 and PRC2 in the fundamental cellular processes and their involvement in human pathologies such as cancer attracted intense attention over the last few decades. Here, we review recent advancements regarding PRC1 and PRC2 function using the zebrafish model. We point out that the unique characteristics of the zebrafish model provide an exceptional opportunity to increase our knowledge of the role of the PRC1 and PRC2 complexes in tissue development, in the maintenance of organ integrity and in pathology.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping