PUBLICATION
Effects of Nutritionally Induced Obesity on Metabolic Pathways of Zebrafish
- Authors
- Li, X., Ge, G., Song, G., Li, Q., Cui, Z.
- ID
- ZDB-PUB-230212-28
- Date
- 2023
- Source
- International Journal of Molecular Sciences 24(3): (Journal)
- Registered Authors
- Cui, Zongbin, Li, Qing, Li, Xixi, Song, Guili
- Keywords
- Zebrafish, intestinal microflora, obesity, signal pathways, transcriptome sequencing
- MeSH Terms
-
- Animals
- Diabetes Mellitus, Type 2*/metabolism
- Diet, High-Fat/adverse effects
- Humans
- Insulin Resistance*
- Liver/metabolism
- Metabolic Networks and Pathways
- Mice
- Mice, Inbred C57BL
- Non-alcoholic Fatty Liver Disease*/metabolism
- Obesity/metabolism
- Zebrafish
- PubMed
- 36768175 Full text @ Int. J. Mol. Sci.
Citation
Li, X., Ge, G., Song, G., Li, Q., Cui, Z. (2023) Effects of Nutritionally Induced Obesity on Metabolic Pathways of Zebrafish. International Journal of Molecular Sciences. 24(3):.
Abstract
Human obesity has become a global epidemic that can lead to many metabolic diseases, including insulin resistance, type 2 diabetes, dyslipidemia, hypertension and nonalcoholic fatty liver. The development of obesity is closely associated with excess food intake and energy imbalance, family history, lifestyle, psychology and other factors, but molecular mechanisms underlying the induction and development of obesity remain to be intensively studied under a variety of internal and external pathogenesis conditions. In this study, we generated two obesity models of zebrafish that were treated with a high-fat diet (HFD) or an overfeeding diet (DIO). Both HFD and DIO zebrafish exhibited higher levels of lipid accumulation, fat distribution, microvascular steatosis and ectopic accumulation of lipid droplets in liver and muscle than normal diet (NOD) fish. The comparison of transcriptome sequencing data for the livers of HFD, DIO and NOD groups identified common and specific genes and signaling pathways that are potentially associated with zebrafish obesity induced by HFD and/or DIO. These findings provide clues for further understanding the mechanisms of obesity development and preventing nutritionally induced obesity through targeting the common signaling pathways and biological processes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping