PUBLICATION
A brainstem integrator for self-location memory and positional homeostasis in zebrafish
- Authors
- Yang, E., Zwart, M.F., James, B., Rubinov, M., Wei, Z., Narayan, S., Vladimirov, N., Mensh, B.D., Fitzgerald, J.E., Ahrens, M.B.
- ID
- ZDB-PUB-221224-40
- Date
- 2022
- Source
- Cell 185: 50115027.e205011-5027.e20 (Journal)
- Registered Authors
- Ahrens, Misha, Narayan, Sujatha
- Keywords
- brainstem, cerebellum, hippocampus, inferior olive, memory, motor control, navigation, neural circuits, neuroscience, path integration, zebrafish
- MeSH Terms
-
- Animals
- Brain/physiology
- Homeostasis
- Mammals
- Neurons*/physiology
- Rhombencephalon/physiology
- Swimming/physiology
- Zebrafish*/physiology
- PubMed
- 36563666 Full text @ Cell
Citation
Yang, E., Zwart, M.F., James, B., Rubinov, M., Wei, Z., Narayan, S., Vladimirov, N., Mensh, B.D., Fitzgerald, J.E., Ahrens, M.B. (2022) A brainstem integrator for self-location memory and positional homeostasis in zebrafish. Cell. 185:50115027.e205011-5027.e20.
Abstract
To track and control self-location, animals integrate their movements through space. Representations of self-location are observed in the mammalian hippocampal formation, but it is unknown if positional representations exist in more ancient brain regions, how they arise from integrated self-motion, and by what pathways they control locomotion. Here, in a head-fixed, fictive-swimming, virtual-reality preparation, we exposed larval zebrafish to a variety of involuntary displacements. They tracked these displacements and, many seconds later, moved toward their earlier location through corrective swimming ("positional homeostasis"). Whole-brain functional imaging revealed a network in the medulla that stores a memory of location and induces an error signal in the inferior olive to drive future corrective swimming. Optogenetically manipulating medullary integrator cells evoked displacement-memory behavior. Ablating them, or downstream olivary neurons, abolished displacement corrections. These results reveal a multiregional hindbrain circuit in vertebrates that integrates self-motion and stores self-location to control locomotor behavior.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping