PUBLICATION
Zebrafish: an important model for understanding scoliosis
- Authors
- Xie, H., Li, M., Kang, Y., Zhang, J., Zhao, C.
- ID
- ZDB-PUB-220907-35
- Date
- 2022
- Source
- Cellular and molecular life sciences : CMLS 79: 506 (Review)
- Registered Authors
- Keywords
- Cerebrospinal fluid flow, Cilia, Reissner’s fiber, Scoliosis, Urotensin signaling, Zebrafish
- MeSH Terms
-
- Animals
- Humans
- Scoliosis*/genetics
- Zebrafish/genetics
- PubMed
- 36059018 Full text @ Cell. Mol. Life Sci.
Citation
Xie, H., Li, M., Kang, Y., Zhang, J., Zhao, C. (2022) Zebrafish: an important model for understanding scoliosis. Cellular and molecular life sciences : CMLS. 79:506.
Abstract
Scoliosis is a common spinal deformity that considerably affects the physical and psychological health of patients. Studies have shown that genetic factors play an important role in scoliosis. However, its etiopathogenesis remain unclear, partially because of the genetic heterogeneity of scoliosis and the lack of appropriate model systems. Recently, the development of efficient gene editing methods and high-throughput sequencing technology has made it possible to explore the underlying pathological mechanisms of scoliosis. Owing to their susceptibility for developing scoliosis and high genetic homology with human, zebrafish are increasingly being used as a model for scoliosis in developmental biology, genetics, and clinical medicine. Here, we summarize the recent advances in scoliosis research on zebrafish and discuss the prospects of using zebrafish as a scoliosis model.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping