PUBLICATION
Treatment of infection-induced vascular pathologies is protective against persistent rough morphotype Mycobacterium abscessus infection in zebrafish
- Authors
- Kam, J.Y., Wright, K., Britton, W.J., Oehlers, S.H.
- ID
- ZDB-PUB-220520-13
- Date
- 2022
- Source
- Microbial pathogenesis 167: 105590 (Journal)
- Registered Authors
- Oehlers, Stefan
- Keywords
- Angiogenesis, Mycobacteria, Platelet, Vascular permeability, Zebrafish
- MeSH Terms
-
- Animals
- Mycobacterium*
- Mycobacterium Infections, Nontuberculous*/microbiology
- Mycobacterium abscessus*
- Zebrafish
- PubMed
- 35588967 Full text @ Microb. Pathog.
Citation
Kam, J.Y., Wright, K., Britton, W.J., Oehlers, S.H. (2022) Treatment of infection-induced vascular pathologies is protective against persistent rough morphotype Mycobacterium abscessus infection in zebrafish. Microbial pathogenesis. 167:105590.
Abstract
Mycobacterium abscessus infections are of increasing global prevalence and are often difficult to treat due to complex antibiotic resistance profiles. While there are similarities between the pathogenesis of M. abscessus and tuberculous mycobacteria, including granuloma formation and stromal remodelling, there are distinct molecular differences at the host-pathogen interface. Here we have used a zebrafish-M. abscessus model and host-directed therapies that were previously identified in the zebrafish-M. marinum model to identify potential host-directed therapies against M. abscessus infection. We find efficacy of anti-angiogenic and vascular normalizing therapies against rough M. abscessus infection, but no effect of anti-platelet drugs.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping