Person
Oehlers, Stefan
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Biography and Research Interest
Tuberculosis pathogenesis and host-directed therapies
Novel host-directed therapies against tuberculosis (TB) are required to overcome the threat posed by multidrug resistant Mycobacterium tuberculosis. Pathogenic mycobacteria modify or co-opt a range of evolutionarily conserved host responses to infection to successfully establish persistent granulomatous infections. We have shown that inhibiting angiogenesis in zebrafish models of mycobacterial infection reduces the growth and spread of mycobacteria by limiting the supply of oxygen to granulomas. Thrombosis is another basic and conserved response to infection that may aid the survival of mycobacteria in granulomas by redirecting the immune response.
Mycobacterium abscessus pathogenesis
The NTM species M. abscessus is an important antibiotic resistant respiratory pathogen. Our lab utilises host (zebrafish-led) genetics and live imaging techniques, and molecular bacteriology tools to compare the differences between M. abscessus and tuberculous mycobacterial infections.
Biography (where you may remember Stefan from)
BSc, BSc(Hons), PhD at the Crosier Lab, University of Auckland 2004-2012
Postdoc at the Tobin Lab, Duke Department of Molecular Genetics and Microbiology 2012-2016
PI at Centenary Institute and The University of Sydney 2016-2021
PI at A*STAR Infectious Diseases Labs 2022-current
Novel host-directed therapies against tuberculosis (TB) are required to overcome the threat posed by multidrug resistant Mycobacterium tuberculosis. Pathogenic mycobacteria modify or co-opt a range of evolutionarily conserved host responses to infection to successfully establish persistent granulomatous infections. We have shown that inhibiting angiogenesis in zebrafish models of mycobacterial infection reduces the growth and spread of mycobacteria by limiting the supply of oxygen to granulomas. Thrombosis is another basic and conserved response to infection that may aid the survival of mycobacteria in granulomas by redirecting the immune response.
Mycobacterium abscessus pathogenesis
The NTM species M. abscessus is an important antibiotic resistant respiratory pathogen. Our lab utilises host (zebrafish-led) genetics and live imaging techniques, and molecular bacteriology tools to compare the differences between M. abscessus and tuberculous mycobacterial infections.
Biography (where you may remember Stefan from)
BSc, BSc(Hons), PhD at the Crosier Lab, University of Auckland 2004-2012
Postdoc at the Tobin Lab, Duke Department of Molecular Genetics and Microbiology 2012-2016
PI at Centenary Institute and The University of Sydney 2016-2021
PI at A*STAR Infectious Diseases Labs 2022-current
Non-Zebrafish Publications