PUBLICATION
Research Techniques Made Simple: Zebrafish Models for Human Dermatologic Disease
- Authors
- Frantz, W.T., Ceol, C.J.
- ID
- ZDB-PUB-220222-5
- Date
- 2022
- Source
- The Journal of investigative dermatology 142: 499-506.e1 (Other)
- Registered Authors
- Ceol, Craig
- Keywords
- none
- MeSH Terms
-
- Animals
- Disease Models, Animal
- Humans
- Melanoma*/pathology
- Mice
- Research Design
- Vitiligo*
- Zebrafish
- PubMed
- 35184798 Full text @ J. Invest. Dermatol.
Citation
Frantz, W.T., Ceol, C.J. (2022) Research Techniques Made Simple: Zebrafish Models for Human Dermatologic Disease. The Journal of investigative dermatology. 142:499-506.e1.
Abstract
Skin diseases affect nearly one third of the world's population. Disease types range from oncologic to inflammatory, and outcomes can be as severe as death and disfigurement. Although many skin diseases have been modeled in murine models, the advantages of zebrafish models have led to recent increasing use in modeling human disease. Their rapid development, comparable skin architecture, tractable genetics, unparalleled optical properties, and straightforward drug screens make them an excellent model to study skin disease. In this review, we discuss the attributes of the zebrafish model system as well as current zebrafish models for dermatologic diseases, including melanoma, squamous cell carcinoma, vitiligo, epidermal bullosa, psoriasis, and wounding.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping