PUBLICATION
Anatomy and development of the pectoral fin vascular network in the zebrafish
- Authors
- Paulissen, S., Castranova, D., Krispin, S., Burns, M.C., Menéndez, J., Torres-Vázquez, J., Weinstein, B.M.
- ID
- ZDB-PUB-220209-7
- Date
- 2022
- Source
- Development (Cambridge, England) 149(5): (Journal)
- Registered Authors
- Castranova, Dan, Paulissen, Scott, Torres-Vazquez, Jesus, Weinstein, Brant M.
- Keywords
- Artery, Endothelial, Forelimb development, Pectoral fin, Vein
- MeSH Terms
-
- Animal Fins/anatomy & histology*
- Animal Fins/growth & development*
- Animals
- Zebrafish/anatomy & histology*
- Zebrafish/growth & development*
- PubMed
- 35132436 Full text @ Development
Citation
Paulissen, S., Castranova, D., Krispin, S., Burns, M.C., Menéndez, J., Torres-Vázquez, J., Weinstein, B.M. (2022) Anatomy and development of the pectoral fin vascular network in the zebrafish. Development (Cambridge, England). 149(5):.
Abstract
The pectoral fins of teleost fish are analogous structures to human forelimbs, and the developmental mechanisms directing their initial growth and patterning are conserved between fish and tetrapods. The forelimb vasculature is critical for limb function, and it appears to play important roles during development by promoting development of other limb structures, but the steps leading to its formation are poorly understood. In this study, we use high-resolution imaging to document the stepwise assembly of the zebrafish pectoral fin vasculature. We show that fin vascular network formation is a stereotyped, choreographed process that begins with the growth of an initial vascular loop around the pectoral fin. This loop connects to the dorsal aorta to initiate pectoral vascular circulation. Pectoral fin vascular development continues with concurrent formation of three elaborate vascular plexuses, one in the distal fin that develops into the fin ray vasculature and two near the base of the fin in association with the developing fin musculature. Our findings detail a complex yet highly choreographed series of steps involved in the development of a complete, functional organ-specific vascular network.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping