PUBLICATION
The organization of the zebrafish pallium from a hodological perspective
- Authors
- Yáñez, J., Folgueira, M., Lamas, I., Anadón, R.
- ID
- ZDB-PUB-211027-4
- Date
- 2021
- Source
- The Journal of comparative neurology 530(8): 1164-1194 (Journal)
- Registered Authors
- Folgueira Otero, Monica
- Keywords
- Danio rerio, DiI, connectome, neural tracing, telencephalon
- MeSH Terms
-
- Animals
- Cerebral Cortex
- Efferent Pathways
- Olfactory Bulb
- Telencephalon*
- Zebrafish*
- PubMed
- 34697803 Full text @ J. Comp. Neurol.
Citation
Yáñez, J., Folgueira, M., Lamas, I., Anadón, R. (2021) The organization of the zebrafish pallium from a hodological perspective. The Journal of comparative neurology. 530(8):1164-1194.
Abstract
We studied the connections (connectome) of the adult zebrafish pallium using carbocyanine dye tracing and ancillary anatomical methods. The everted zebrafish pallium (dorsal telencephalic area, D) is comprised of several major zones (medial, lateral, dorsal, central, anterior and posterior) distinguishable by their topography, cytoarchitecture, immunohistochemistry and genoarchitecture. Our comprehensive study reveals poor interconnectivity between these pallial areas, especially between medial (Dm), lateral/dorsal (Dl, Dd) and posterior (Dp) regions. This suggests that the zebrafish pallium has dedicated modules for different neural processes. Pallial connections with extrapallial regions also show compartmental organization. Major extratelencephalic afferents come from preglomerular nuclei (to Dl, Dd and Dm), posterior tuberal nucleus (to Dm), and lateral recess nucleus (to Dl). The subpallial (ventral, V) zones dorsal Vv, Vd and Vs, considered homologues of the striatum, amygdala and pallidum, are mainly afferent to Dl/Dd and Dp. Regarding the efferent pathways, they also appear characteristic of each pallial region. Rostral Dm projects to the dorsal entopeduncular nucleus. Dp is interconnected with the olfactory bulbs. The central region (Dc) defined here receives mainly projections from Dl-Dd and projects toward the pretectum and optic tectum, connections, which help to delimiting Dc. The connectome of the adult pallium revealed here complements extant studies on the neuroanatomical organization of the brain, and may be useful for neurogenetic studies performed during early stages of development. The connectome of the zebrafish pallium was also compared with the pallial connections reported in other teleosts, a large group showing high pallial diversity. This article is protected by copyright. All rights reserved.
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Human Disease / Model
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