PUBLICATION
Ongoing habenular activity is driven by forebrain networks and modulated by olfactory stimuli
- Authors
- Bartoszek, E.M., Ostenrath, A.M., Jetti, S.K., Serneels, B., Mutlu, A.K., Chau, K.T.P., Yaksi, E.
- ID
- ZDB-PUB-210821-12
- Date
- 2021
- Source
- Current biology : CB 31(17): 3861-3874.e3 (Journal)
- Registered Authors
- Bartoszek, Ewelina, Jetti, Suresh Kumar, Yaksi, Emre
- Keywords
- forebrain, functional connectivity, habenula, internal state, limbic system, neural circuits, olfaction, ongoing activity, two-photon calcium imaging, zebrafish
- MeSH Terms
-
- Animals
- Habenula*/physiology
- Nervous System
- Neurons
- Smell
- Zebrafish/physiology
- PubMed
- 34416179 Full text @ Curr. Biol.
Citation
Bartoszek, E.M., Ostenrath, A.M., Jetti, S.K., Serneels, B., Mutlu, A.K., Chau, K.T.P., Yaksi, E. (2021) Ongoing habenular activity is driven by forebrain networks and modulated by olfactory stimuli. Current biology : CB. 31(17):3861-3874.e3.
Abstract
Ongoing neural activity, which represents internal brain states, is constantly modulated by the sensory information that is generated by the environment. In this study, we show that the habenular circuits act as a major brain hub integrating the structured ongoing activity of the limbic forebrain circuitry and the olfactory information. We demonstrate that ancestral homologs of amygdala and hippocampus in zebrafish forebrain are the major drivers of ongoing habenular activity. We also reveal that odor stimuli can modulate the activity of specific habenular neurons that are driven by this forebrain circuitry. Our results highlight a major role for the olfactory system in regulating the ongoing activity of the habenula and the forebrain, thereby altering brain's internal states.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping