PUBLICATION
Evaluation of the Antidiabetic and Antihyperlipidemic Activity of Spondias purpurea Seeds in a Diabetic Zebrafish Model
- Authors
- Muñiz-Ramirez, A., Garcia-Campoy, A.H., Pérez Gutiérrez, R.M., Garcia Báez, E.V., Mota Flores, J.M.
- ID
- ZDB-PUB-210811-2
- Date
- 2021
- Source
- Plants (Basel, Switzerland) 10(7): (Journal)
- Registered Authors
- Keywords
- Spondias purpurea, antiglycation activity, diabetes, zebrafish
- MeSH Terms
- none
- PubMed
- 34371620 Full text @ Plants (Basel)
Citation
Muñiz-Ramirez, A., Garcia-Campoy, A.H., Pérez Gutiérrez, R.M., Garcia Báez, E.V., Mota Flores, J.M. (2021) Evaluation of the Antidiabetic and Antihyperlipidemic Activity of Spondias purpurea Seeds in a Diabetic Zebrafish Model. Plants (Basel, Switzerland). 10(7):.
Abstract
Diabetes mellitus (DM) is a serious chronic degenerative disease characterized by high levels of glucose in the blood. It is associated with an absolute or relative deficiency in the production and/or action of insulin. Some of the complications associated with DM are heart disease, retinopathy, kidney disease, and neuropathy; therefore, new natural alternatives are being sought to control the disease. In this work, we evaluate the antidiabetic effect of Spondias purpurea seed methanol extract (CSM) in vitro and in a glucose-induced diabetic zebrafish model. CSM is capable of lowering blood glucose and cholesterol levels, as well as forming advanced glycation end-products, while not presenting toxic effects at the concentrations evaluated. These data show that CSM has a promising antidiabetic effect and may be useful in reducing some of the pathologies associated with diabetes mellitus.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping