ZFIN ID: ZDB-PUB-210209-11
Targeting ganglioneuromas with mTOR inhibitors
Tao, T., Shi, H., Durbin, A.D., Look, A.T.
Date: 2021
Source: Molecular & cellular oncology   8: 1856621 (Other)
Registered Authors: Durbin, Adam, Look, A. Thomas
Keywords: AKT, Ganglioneuroma, mTOR inhibitor, zebrafish model
MeSH Terms: none
PubMed: 33553609 Full text @ Mol Cell Oncol
ABSTRACT
We recently identified activated protein kinase B (PKB/AKT) as a tumorigenic driver in childhood ganglioneuroma. Inhibition of the mechanistic target of rapamycin (mTOR), a serine/threonine kinase downstream of AKT, effectively reduced the tumor burden in zebrafish with ganglioneuroma. We propose a clinical trial of mTOR inhibitors as a means to shrink large ganglioneuromas prior to surgical resection.
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