PUBLICATION
Polydatin Beneficial Effects in Zebrafish Larvae Undergoing Multiple Stress Types
- Authors
- Pessina, A., Di Vincenzo, M., Maradonna, F., Marchegiani, F., Olivieri, F., Randazzo, B., Gioacchini, G., Carnevali, O.
- ID
- ZDB-PUB-210131-3
- Date
- 2021
- Source
- International Journal of Environmental Research and Public Health 18(3): (Journal)
- Registered Authors
- Carnevali, Oliana
- Keywords
- Danio rerio, anti-inflammatory, antioxidant, immune system, interleukins, polyphenols
- MeSH Terms
-
- Animals
- Glucosides/pharmacology
- Larva
- Oxidative Stress
- Stilbenes*/pharmacology
- Zebrafish*
- PubMed
- 33513921 Full text @ Int. J. Environ. Res. Public Health
Citation
Pessina, A., Di Vincenzo, M., Maradonna, F., Marchegiani, F., Olivieri, F., Randazzo, B., Gioacchini, G., Carnevali, O. (2021) Polydatin Beneficial Effects in Zebrafish Larvae Undergoing Multiple Stress Types. International Journal of Environmental Research and Public Health. 18(3):.
Abstract
Polydatin is a polyphenol, whose beneficial properties, including anti-inflammatory and antioxidant activity, have been largely demonstrated. At the same time, copper has an important role in the correct organism homeostasis and alteration of its concentration can induce oxidative stress. In this study, the efficacy of polydatin to counteract the stress induced by CuSO4 exposure or by caudal fin amputation was investigated in zebrafish larvae. The study revealed that polydatin can reduced the stress induced by a 2 h exposure to 10 µM CuSO4 by lowering the levels of il1b and cxcl8b.1 and reducing neutrophils migration in the head and along the lateral line. Similarly, polydatin administration reduced the number of neutrophils in the area of fin cut. In addition, polydatin upregulates the expression of sod1 mRNA and CAT activity, both involved in the antioxidant response. Most of the results obtained in this study support the working hypothesis that polydatin administration can modulate stress response and its action is more effective in mitigating the effects rather than in preventing chemical damages.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping