PUBLICATION
Habenula as the experience-dependent controlling switchboard of behavior and attention in social conflict and learning
- Authors
- Okamoto, H., Cherng, B.W., Nakajo, H., Chou, M.Y., Kinoshita, M.
- ID
- ZDB-PUB-210110-11
- Date
- 2021
- Source
- Current opinion in neurobiology 68: 36-43 (Review)
- Registered Authors
- Chou, Ming-Yi, Okamoto, Hitoshi
- Keywords
- none
- MeSH Terms
-
- Animals
- Attention
- Habenula*
- Interpeduncular Nucleus*
- Neural Pathways
- Zebrafish
- PubMed
- 33421772 Full text @ Curr. Opin. Neurobiol.
Citation
Okamoto, H., Cherng, B.W., Nakajo, H., Chou, M.Y., Kinoshita, M. (2021) Habenula as the experience-dependent controlling switchboard of behavior and attention in social conflict and learning. Current opinion in neurobiology. 68:36-43.
Abstract
The habenula is among the evolutionarily most conserved parts of the brain and has been known for its role in the control of behavior to cope with aversive stimuli. Recent studies in zebrafish have revealed the novel roles of the two parallel neural pathways from the dorsal habenula to its target, the interpeduncular nucleus, in the control of behavioral choice whether to behave dominantly or submissively in the social conflict. They are modifiable depending on the internal state of the fish such as hunger and play another important role in orientation of attention whether to direct it internally to oneself or externally to others. These studies, therefore, are revealing a novel role for the habenula as the integrated switchboard for concertedly controlling behavior either as a winner with self-centered (idiothetic) attention or a loser with others-oriented (allothetic) attention.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping