PUBLICATION

Chlorogenic Acid Supplementation Benefits Zebrafish Embryos Exposed to Auranofin

Authors
Chiu, J.Z.S., Hold, I., Newman, T.A.C., Horsfield, J.A., McDowell, A.
ID
ZDB-PUB-201217-3
Date
2020
Source
Pharmaceutics   12(12): (Journal)
Registered Authors
Horsfield, Jules
Keywords
Sonchus oleraceus, antioxidant, auranofin, chlorogenic acid, zebrafish
MeSH Terms
none
PubMed
33322287 Full text @ Pharmaceutics
Abstract
Antioxidant supplementation may potentially be beneficial for embryonic development to reduce complications associated with increased levels of oxidative stress. Chlorogenic acid, one of the key polyphenolic antioxidants in S. oleraceus, was evaluated for potential protective effects during embryonic development of zebrafish exposed to the teratogen auranofin. Zebrafish embryos were transiently exposed to auranofin to induce developmental abnormalities. Phenotypic abnormalities were scored based on their severity at day 5 post-fertilization. The embryos supplemented with 250 µM chlorogenic acid showed a significantly lower score in phenotypic abnormalities compared to non-supplemented embryos after auranofin exposure. Therefore, supplementation with a low dose of chlorogenic acid showed a protective effect from auranofin-induced deformities and encouraged normal growth in zebrafish embryos. This study provides further support for the potential of using antioxidant supplementation during embryonic development for protection against malformation.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping