ZFIN ID: ZDB-PERS-011217-2
Horsfield, Jules
Email: julia.horsfield@otago.ac.nz
URL: http://www.otago.ac.nz/csdg
Affiliation: Crosier Lab
and also: Chromosome Structure and Development Group
Address: Department of Pathology Dunedin School of Medicine University of Otago PO BOX 913 Dunedin, New Zealand
Country: New Zealand
Phone: 64 3 479 7436
Fax: 64 3 479 7136

We are interested in how proteins necessary for normal chromosome architecture during the cell cycle can also contribute to gene expression, animal development and cancer. The main focus of our research is exploring alternative roles for proteins needed for sister chromatid cohesion during mitosis.

Chiu, J.Z.S., Hold, I., Newman, T.A.C., Horsfield, J.A., McDowell, A. (2020) Chlorogenic Acid Supplementation Benefits Zebrafish Embryos Exposed to Auranofin. Pharmaceutics. 12(12):
Ketharnathan, S., Labudina, A., Horsfield, J.A. (2020) Cohesin Components Stag1 and Stag2 Differentially Influence Haematopoietic Mesoderm Development in Zebrafish Embryos. Frontiers in cell and developmental biology. 8:617545
Chin, C.V., Antony, J., Ketharnathan, S., Labudina, A., Gimenez, G., Parsons, K.M., He, J., George, A.J., Pallota, M.M., Musio, A., Braithwaite, A.W., Guilford, P., Hannan, R.D., Horsfield, J.A. (2020) Cohesin mutations are synthetic lethal with stimulation of WNT signaling. eLIFE. 9:
Horsfield, J.A. (2019) Packaging development: how chromatin controls transcription in zebrafish embryogenesis. Biochemical Society transactions. 47(2):713-724
Leask, M., Dowdle, A., Salvesen, H., Topless, R., Fadason, T., Wei, W., Schierding, W., Marsman, J., O'Sullivan, J.M., Merriman, T.R., Horsfield, J.A. (2019) Functional Urate-Associated Genetic Variants Influence Expression of lincRNAs LINC01229 and MAFTRR. Frontiers in genetics. 9:733
Ketharnathan, S., Leask, M., Boocock, J., Phipps-Green, A.J., Antony, J., O'Sullivan, J.M., Merriman, T.R., Horsfield, J.A. (2018) A non-coding genetic variant maximally associated with serum urate levels is functionally linked to HNF4A-dependent PDZK1 expression. Human molecular genetics. 27(22):3964-3973
Cukrov, D., Newman, T., Leask, M., Leeke, B., Sarogni, P., Patimo, A., Kline, A.D., Krantz, I.D., Horsfield, J., Musio, A. (2018) Antioxidant treatment ameliorates phenotypic features of SMC1A-mutated Cornelia de Lange syndrome in vitro and in vivo. Human molecular genetics. 27(17):3002-3011
Lee, S.L.J., Horsfield, J.A., Black, M.A., Rutherford, K., Gemmell, N.J. (2017) Identification of sex differences in zebrafish (Danio rerio) brains during early sexual differentiation and masculinisation using 17α-methyltestoterone. Biology of reproduction. 99(2):446-460
Meier, M., Grant, J., Dowdle, A., Thomas, A., Gerton, J., Collas, P., O'Sullivan, J.M., Horsfield, J.A. (2017) Cohesin facilitates zygotic genome activation in zebrafish. Development (Cambridge, England). 145(1)
Marsman, J., Thomas, A., Osato, M., O'Sullivan, J.M., Horsfield, J.A. (2017) A DNA Contact Map for the Mouse Runx1 Gene Identifies Novel Haematopoietic Enhancers. Scientific Reports. 7:13347
Lee, S.L.J., Horsfield, J.A., Black, M.A., Rutherford, K., Fisher, A., Gemmell, N.J. (2017) Histological and transcriptomic effects of 17α-methyltestosterone on zebrafish gonad development. BMC Genomics. 18:557
Stayner, C., Poole, C.A., McGlashan, S.R., Pilanthananond, M., Brauning, R., Markie, D., Lett, B., Slobbe, L., Chae, A., Johnstone, A.C., Jensen, C.G., McEwan, J.C., Dittmer, K., Parker, K., Wiles, A., Blackburne, W., Leichter, A., Leask, M., Pinnapureddy, A., Jennings, M., Horsfield, J.A., Walker, R.J., Eccles, M.R. (2017) An ovine hepatorenal fibrocystic model of a Meckel-like syndrome associated with dysmorphic primary cilia and TMEM67 mutations. Scientific Reports. 7:1601
Newman, T., Jhinku, N., Meier, M., Horsfield, J. (2016) Dietary Intake Influences Adult Fertility and Offspring Fitness in Zebrafish. PLoS One. 11:e0166394
Chatterjee, A., Lagisz, M., Rodger, E.J., Zhen, L., Stockwell, P.A., Duncan, E.J., Horsfield, J.A., Jeyakani, J., Mathavan, S., Ozaki, Y., Nakagawa, S. (2016) Sex differences in DNA methylation and expression in zebrafish brain: a test of an extended 'male sex drive' hypothesis. Gene. 590(2):307-16
Schuster, K., Leeke, B., Meier, M., Wang, Y., Newman, T., Burgess, S., Horsfield, J.A. (2015) A neural crest origin for cohesinopathy heart defects. Human molecular genetics. 24(24):7005-16
Newman, T.A., Carleton, C.R., Leeke, B., Hampton, M.B., Horsfield, J.A. (2015) Embryonic oxidative stress results in reproductive impairment for adult zebrafish. Redox Biology. 6:648-655
Chatterjee, A., Stockwell, P.A., Horsfield, J.A., Morison, I.M., Nakagawa, S. (2014) Base-resolution DNA methylation landscape of zebrafish brain and liver. Genomics Data. 2:342-4
Kline, A.D., Calof, A.L., Schaaf, C.A., Krantz, I.D., Jyonouchi, S., Yokomori, K., Gauze, M., Carrico, C.S., Woodman, J., Gerton, J.L., Vega, H., Levin, A.V., Shirahige, K., Champion, M., Goodban, M.T., O'Connor, J.T., Pipan, M., Horsfield, J., Deardorff, M.A., Ishman, S.L., and Dorsett, D. (2014) Cornelia de Lange syndrome: Further delineation of phenotype, cohesin biology and educational focus, 5th Biennial Scientific and Educational Symposium abstracts. American journal of medical genetics. Part A. 164(6):1384-93
Marsman, J., O'Neill, A.C., Kao, B.R., Rhodes, J.M., Meier, M., Antony, J., Mönnich, M., and Horsfield, J.A. (2014) Cohesin and CTCF differentially regulate spatiotemporal runx1 expression during zebrafish development. Biochimica et biophysica acta. Gene regulatory mechanisms. 1839(1):50-61
Chatterjee, A., Ozaki, Y., Stockwell, P.A., Horsfield, J.A., Morison, I.M., and Nakagawa, S. (2013) Mapping the zebrafish brain methylome using reduced representation bisulfite sequencing. Epigenetics. 8(9):979-89
Horsfield, J.A., Print, C.G., and Mönnich, M. (2012) Diverse developmental disorders from the one ring: distinct molecular pathways underlie the cohesinopathies. Frontiers in Epigenomics. 3:171
Deardorff, M.A., Wilde, J.J., Albrecht, M., Dickinson, E., Tennstedt, S., Braunholz, D., Mönnich, M., Yan, Y., Xu, W., Gil-Rodríguez, M.C., Clark, D., Hakonarson, H., Halbach, S., Michelis, L.D., Rampuria, A., Rossier, E., Spranger, S., Van Maldergem, L., Lynch, S.A., Gillessen-Kaesbach, G., Lüdecke, H.J., Ramsay, R.G., McKay, M.J., Krantz, I.D., Xu, H., Horsfield, J.A., and Kaiser, F.J. (2012) RAD21 Mutations Cause a Human Cohesinopathy. American journal of human genetics. 90(6):1014-1027
Mönnich, M., Kuriger, Z., Print, C.G., and Horsfield, J.A. (2011) A zebrafish model of Roberts syndrome reveals that Esco2 depletion interferes with development by disrupting the cell cycle. PLoS One. 6(5):e20051
Rhodes, J.M., Bentley, F.K., Print, C.G., Dorsett, D., Misulovin, Z., Dickinson, E.J., Crosier, K.E., Crosier, P.S., and Horsfield, J.A. (2010) Positive regulation of c-Myc by cohesin is direct, and evolutionarily conserved. Developmental Biology. 344(2):637-649
Mönnich, M., Banks, S., Eccles, M., Dickinson, E., and Horsfield, J. (2009) Expression of cohesin and condensin genes during zebrafish development supports a non-proliferative role for cohesin. Gene expression patterns : GEP. 9(8):586-594
Horsfield, J.A., Anagnostou, S.H., Hu, J.K., Cho, K.H., Geisler, R., Lieschke, G., Crosier, K.E., and Crosier, P.S. (2007) Cohesin-dependent regulation of Runx genes. Development (Cambridge, England). 134(14):2639-2649
Kalev-Zylinska, M.L., Horsfield, J.A., Flores, M.V., Postlethwait, J.H., Chau, J.Y., Cattin, P.M., Vitas, M.R., Crosier, P.S., and Crosier, K.E. (2003) Runx3 is required for hematopoietic development in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 228(3):323-336
Horsfield, J., Ramachandran, A., Reuter, K., LaVallie, E., Collins-Racie, L., Crosier, K., and Crosier, P. (2002) Cadherin-17 is required to maintain pronephric duct integrity during zebrafish development. Mechanisms of Development. 115(1-2):15-26
Kalev-Zylinska, M.L., Horsfield, J.A., Flores, M.V.C., Postlethwait, J.H., Vitas, M.R., Baas, A.M., Crosier, P.S., and Crosier, K.E. (2002) Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis. Development (Cambridge, England). 129(8):2015-2030
Crosier, P.S., Kalev-Zylinska, M.L., Hall, C.J., Flores, M.V.C., Horsfield, J.A., and Crosier, K.E. (2002) Pathways in blood and vessel development revealed through zebrafish genetics. The International journal of developmental biology. 46(4):493-502
Crosier, P.S., Bardsley, A., Horsfield, J.A., Krassowska, A.K., Lavallie, E.R., Collins-Racie, L.A., Postlethwait, J.H., Yan, Y.-L., McCoy, J.M., and Crosier, K.E. (2001) In situ hybridization screen in zebrafish for the selection of genes encoding secreted proteins. Developmental dynamics : an official publication of the American Association of Anatomists. 222(4):637-644
Kalev, M.L., Horsfield, J.A., Flores, M.C., Postlethwait, J.H., Vitas, M.R., Baas, A.M., Crosier, P.S., and Crosier, K.E. (2001) Runt family transcription factors are required for zebrafish hematopoiesis, and their function is disrupted by a human RUNX1-CBF2T1 transgene. Blood. 98(11):1892