PUBLICATION
Rho GTPases Signaling in Zebrafish Development and Disease
- Authors
- Boueid, M.J., Mikdache, A., Lesport, E., Degerny, C., Tawk, M.
- ID
- ZDB-PUB-201212-27
- Date
- 2020
- Source
- Cells 9(12): (Review)
- Registered Authors
- Boueid, Marie-Jose, Degerny, Cindy, Lesport, Emilie, Tawk, Marcel
- Keywords
- Cdc42, GAP, GEF, Rac, RhoA, small GTPases, zebrafish
- MeSH Terms
-
- Animals
- Cell Movement
- Regeneration
- Signal Transduction
- Zebrafish/growth & development*
- Zebrafish/metabolism
- Zebrafish/physiology
- Zebrafish Proteins/metabolism*
- cdc42 GTP-Binding Protein/genetics
- cdc42 GTP-Binding Protein/metabolism
- rac1 GTP-Binding Protein/genetics
- rac1 GTP-Binding Protein/metabolism
- rho GTP-Binding Proteins/metabolism*
- rhoA GTP-Binding Protein/genetics
- rhoA GTP-Binding Protein/metabolism
- PubMed
- 33302361 Full text @ Cells
Citation
Boueid, M.J., Mikdache, A., Lesport, E., Degerny, C., Tawk, M. (2020) Rho GTPases Signaling in Zebrafish Development and Disease. Cells. 9(12):.
Abstract
Cells encounter countless external cues and the specificity of their responses is translated through a myriad of tightly regulated intracellular signals. For this, Rho GTPases play a central role and transduce signals that contribute to fundamental cell dynamic and survival events. Here, we review our knowledge on how zebrafish helped us understand the role of some of these proteins in a multitude of in vivo cellular behaviors. Zebrafish studies offer a unique opportunity to explore the role and more specifically the spatial and temporal dynamic of Rho GTPases activities within a complex environment at a level of details unachievable in any other vertebrate organism.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping