PUBLICATION
Acute Restraint Stress Evokes Anxiety-Like Behavior Mediated by Telencephalic Inactivation and GabAergic Dysfunction in Zebrafish Brains
- Authors
- Assad, N., Luz, W.L., Santos-Silva, M., Carvalho, T., Moraes, S., Picanço-Diniz, D.L.W., Bahia, C.P., Oliveira Batista, E.J., da Conceição Passos, A., Oliveira, K.R.H.M., Herculano, A.M.
- ID
- ZDB-PUB-200403-197
- Date
- 2020
- Source
- Scientific Reports 10: 5551 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Behavior, Animal
- Disease Models, Animal
- Glutamic Acid/metabolism
- Receptors, GABA-A/metabolism*
- Signal Transduction
- Stress, Psychological/metabolism*
- Telencephalon/metabolism*
- Zebrafish
- gamma-Aminobutyric Acid/metabolism*
- PubMed
- 32218457 Full text @ Sci. Rep.
Citation
Assad, N., Luz, W.L., Santos-Silva, M., Carvalho, T., Moraes, S., Picanço-Diniz, D.L.W., Bahia, C.P., Oliveira Batista, E.J., da Conceição Passos, A., Oliveira, K.R.H.M., Herculano, A.M. (2020) Acute Restraint Stress Evokes Anxiety-Like Behavior Mediated by Telencephalic Inactivation and GabAergic Dysfunction in Zebrafish Brains. Scientific Reports. 10:5551.
Abstract
Acute stress is an important factor in the development of anxiety disorders. Zebrafish are an organism model widely used by studies that aim to describe the events in the brain that control stress-elicited anxiety. The goal of the current study was to evaluate the pattern of cell activation in the telencephalon of adult zebrafish and the role of the GABAergic system on the modulation of anxiety-like behavior evoked by acute restraint stress. Zebrafish that underwent acute restraint stress presented decreased expression of the c-fos protein in their telencephalon as well as a significant decrease in GABA release. The data also supports that decreased GABA levels in zebrafish brains have diminished the activation of GABAA receptors eliciting anxiety-like behavior. Taken together these findings have helped clarify a neurochemical pathway controlling anxiety-like behavior evoked by acute stress in zebrafish while also opening the possibility of new perspective opportunities to use zebrafish as an animal model to test anxyolitic drugs that target the GABAergic system.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping