PUBLICATION

Nanoemulsified adlay bran oil reduces tyrosinase activity and melanin synthesis in B16F10 cells and zebrafish

Authors
Ting, Y., Hu, Y.T., Hu, J.Y., Chang, W.C., Huang, Q., Hsieh, S.C.
ID
ZDB-PUB-191030-5
Date
2019
Source
Food science & nutrition   7: 3216-3223 (Journal)
Registered Authors
Chang, Wen-Chang
Keywords
adlay bran oil, anti‐hyperpigmentation, melanin, nanoemulsion, tyrosinase, zebrafish
MeSH Terms
none
PubMed
31660135 Full text @ Food Sci Nutr
Abstract
The efficacy of oily components is often difficult to evaluate due to their incompatibility with most models. Here, we emulsified adlay bran oil (ABO), processed it to a nanoscale, and investigated its anti-hyperpigmentation efficacy, assessed for its inhibitory effects against tyrosinase activity and melanin production, in an in vitro system (mouse melanoma B16F10 cells) and an in vivo system (zebrafish embryos). ABO induced dose-dependent reductions in tyrosinase activity and melanin production in both the melanoma cells and zebrafish, without affecting viability. The efficacy of ABO was strongly influenced by emulsion particle size in the zebrafish but not in the cells. These results indicate that ABO has potential as a tyrosinase inhibitor and anti-hyperpigmentation agent and that the emulsion system is an effective method for delivering the bioactive components of ABO to living systems that could be utilized for other oily components.
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