PUBLICATION
Adult sox10+ Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish
- Authors
- Sande-Melón, M., Marques, I.J., Galardi-Castilla, M., Langa, X., Pérez-López, M., Botos, M.A., Sánchez-Iranzo, H., Guzmán-Martínez, G., Ferreira Francisco, D.M., Pavlinic, D., Benes, V., Bruggmann, R., Mercader, N.
- ID
- ZDB-PUB-191024-7
- Date
- 2019
- Source
- Cell Reports 29: 1041-1054.e5 (Journal)
- Registered Authors
- Marques, Ines, Mercader Huber, Nadia
- Keywords
- cardiomyocyte proliferation, heart regeneration, sox10, zebrafish
- Datasets
- GEO:GSE133571
- MeSH Terms
-
- Animals
- Cell Proliferation
- Cells, Cultured
- Heart/physiology
- Myocytes, Cardiac/metabolism*
- Myocytes, Cardiac/physiology
- Regeneration*
- SOXE Transcription Factors/genetics
- SOXE Transcription Factors/metabolism*
- Zebrafish
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- PubMed
- 31644901 Full text @ Cell Rep.
Citation
Sande-Melón, M., Marques, I.J., Galardi-Castilla, M., Langa, X., Pérez-López, M., Botos, M.A., Sánchez-Iranzo, H., Guzmán-Martínez, G., Ferreira Francisco, D.M., Pavlinic, D., Benes, V., Bruggmann, R., Mercader, N. (2019) Adult sox10+ Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish. Cell Reports. 29:1041-1054.e5.
Abstract
During heart regeneration in the zebrafish, fibrotic tissue is replaced by newly formed cardiomyocytes derived from preexisting ones. It is unclear whether the heart is composed of several cardiomyocyte populations bearing different capacity to replace lost myocardium. Here, using sox10 genetic fate mapping, we identify a subset of preexistent cardiomyocytes in the adult zebrafish heart with a distinct gene expression profile that expanded after cryoinjury. Genetic ablation of sox10+ cardiomyocytes impairs cardiac regeneration, revealing that these cells play a role in heart regeneration.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping