PUBLICATION
Model systems for regeneration: zebrafish
- Authors
- Marques, I.J., Lupi, E., Mercader, N.
- ID
- ZDB-PUB-190922-1
- Date
- 2019
- Source
- Development (Cambridge, England) 146(18): (Other)
- Registered Authors
- Marques, Ines, Mercader Huber, Nadia
- Keywords
- Cell progenitors, Genetic tools, Injury methods, Regeneration, Zebrafish
- MeSH Terms
-
- Animals
- Drug Evaluation, Preclinical
- Genetic Techniques
- Humans
- Models, Animal*
- Organogenesis
- Regeneration/physiology*
- Zebrafish/physiology*
- PubMed
- 31540899 Full text @ Development
Citation
Marques, I.J., Lupi, E., Mercader, N. (2019) Model systems for regeneration: zebrafish. Development (Cambridge, England). 146(18).
Abstract
Tissue damage can resolve completely through healing and regeneration, or can produce permanent scarring and loss of function. The response to tissue damage varies across tissues and between species. Determining the natural mechanisms behind regeneration in model organisms that regenerate well can help us develop strategies for tissue recovery in species with poor regenerative capacity (such as humans). The zebrafish (Danio rerio) is one of the most accessible vertebrate models to study regeneration. In this Primer, we highlight the tools available to study regeneration in the zebrafish, provide an overview of the mechanisms underlying regeneration in this system and discuss future perspectives for the field.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping