ZFIN ID: ZDB-PUB-190712-18
Evolutionary Origin and Nomenclature of Vertebrate Wnt11-Family Genes
Postlethwait, J.H., Navajas Acedo, J., Piotrowski, T.
Date: 2019
Source: Zebrafish   16(5): 469-476 (Journal)
Registered Authors: Navajas Acedo, Joaquin, Piotrowski, Tatjana, Postlethwait, John H.
Keywords: Wnt signaling, Wnt11, Wnt11r, conserved synteny, ohnolog, whole-genome duplication
MeSH Terms:
  • Animals
  • Biological Evolution*
  • Genome
  • Humans
  • Multigene Family/genetics
  • Synteny
  • Terminology as Topic
  • Vertebrates/genetics
  • Vertebrates/metabolism*
  • Wnt Proteins/classification
  • Wnt Proteins/genetics
  • Wnt Proteins/metabolism*
PubMed: 31295059 Full text @ Zebrafish
To adequately connect zebrafish medical models to human biology, it is essential that gene nomenclature reflects gene orthology. Analysis of gene phylogenies and conserved syntenies shows that the zebrafish gene currently called wnt11 (ENSDARG00000004256, ZFIN ID: ZDB-GENE-990603-12) is not the ortholog of the human gene called WNT11 (ENSG00000085741); instead, the gene currently called wnt11r (ENSDARG00000014796, ZFIN ID: ZDB-GENE-980526-249) is the zebrafish ortholog of human WNT11. Genomic analysis of Wnt11-family genes suggests a model for the birth of Wnt11-family gene ohnologs in genome duplication events, provides a mechanism for the death of a Wnt11-family ohnolog in mammals after they diverged from birds, and suggests revised nomenclature to better connect teleost disease models to human biology.