PUBLICATION
'Central' Actions of Corticosteroid Signaling Suggested by Constitutive Knockout of Corticosteroid Receptors in Small Fish
- Authors
- Sakamoto, T., Sakamoto, H.
- ID
- ZDB-PUB-190316-1
- Date
- 2019
- Source
- Nutrients 11(3): (Review)
- Registered Authors
- Sakamoto, Hirotaka
- Keywords
- behavior, brain, glucocorticoid, metabolism, mineralocorticoid, vision
- MeSH Terms
-
- Adrenal Cortex Hormones/metabolism*
- Animals
- Behavior, Animal/physiology*
- Gene Deletion*
- Receptors, Steroid/genetics*
- Receptors, Steroid/metabolism*
- Signal Transduction
- Zebrafish/genetics*
- PubMed
- 30871191 Full text @ Nutrients
Citation
Sakamoto, T., Sakamoto, H. (2019) 'Central' Actions of Corticosteroid Signaling Suggested by Constitutive Knockout of Corticosteroid Receptors in Small Fish. Nutrients. 11(3).
Abstract
This review highlights recent studies of the functional implications of corticosteroids in some important behaviors of model fish, which are also relevant to human nutrition homeostasis. The primary actions of corticosteroids are mediated by glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), which are transcription factors. Zebrafish and medaka models of GR- and MR-knockout are the first constitutive corticosteroid receptor-knockout animals that are viable in adulthood. Similar receptor knockouts in mice are lethal. In this review, we describe the physiological and behavioral changes following disruption of the corticosteroid receptors in these models. The GR null model has peripheral changes in nutrition metabolism that do not occur in a mutant harboring a point mutation in the GR DNA-binding domain. This suggests that these are not "intrinsic" activities of GR. On the other hand, we propose that integration of visual responses and brain behavior by corticosteroid receptors is a possible "intrinsic"/principal function potentially conserved in vertebrates.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping