PUBLICATION

Mesencephalic origin of the inferior lobe in zebrafish

Authors
Bloch, S., Thomas, M., Colin, I., Galant, S., Machado, E., Affaticati, P., Jenett, A., Yamamoto, K.
ID
ZDB-PUB-190310-1
Date
2019
Source
BMC Biology   17: 22 (Journal)
Registered Authors
Colin, Ingrid, Yamamoto, Kei
Keywords
Cell lineage, Comparative neuroanatomy, Development, Evolution, Forebrain, Homology, Midbrain, Teleost, Ventricle, Vertebrate
MeSH Terms
  • Biological Evolution
  • Prosencephalon/cytology
  • Prosencephalon/embryology*
  • Zebrafish/embryology*
  • Animals
  • Mesencephalon/cytology
  • Mesencephalon/embryology*
  • Cell Lineage/physiology
  • Neural Stem Cells/cytology
(all 9)
PubMed
30849972 Full text @ BMC Biol.
Abstract
Background Although the overall brain organization is shared in vertebrates, there are significant differences within subregions among different groups, notably between Sarcopterygii (lobe-finned fish) and Actinopterygii (ray-finned fish). Recent comparative studies focusing on the ventricular morphology have revealed a large diversity of the hypothalamus. Here, we study the development of the inferior lobe (IL), a prominent structure forming a bump on the ventral surface of the teleost brain. Based on its position, IL has been thought to be part of the hypothalamus (therefore forebrain).
Results Taking advantage of genetic lineage-tracing techniques in zebrafish, we reveal that cells originating from her5-expressing progenitors in the midbrain-hindbrain boundary (MHB) participate in the formation of a large part of the IL. 3D visualization demonstrated how IL develops in relation to the ventricular system. We found that IL is constituted by two developmental components: the periventricular zone of hypothalamic origin and the external zone of mesencephalic origin. The mesencephalic external zone grows progressively until adulthood by adding new cells throughout development.
Conclusion Our results disprove a homology between the IL and the mammalian lateral hypothalamus. We suggest that the IL is likely to be involved in multimodal sensory integration rather than feeding motivation. The teleost brain is not a simpler version of the mammalian brain, and our study highlights the evolutionary plasticity of the brain which gives rise to novel structures.
Genes / Markers
Figures
Figure Gallery (11 images) / 2
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Expression
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
gy3TgTransgenic Insertion
    gy4TgTransgenic Insertion
      jh15TgTransgenic Insertion
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        Human Disease / Model
        No data available
        Sequence Targeting Reagents
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        Fish
        No data available
        Antibodies
        Orthology
        No data available
        Engineered Foreign Genes
        Marker Marker Type Name
        CreEFGCre
        EGFPEFGEGFP
        mCherryEFGmCherry
        1 - 3 of 3
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        Mapping
        No data available
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        Citation
        Bloch, S., Thomas, M., Colin, I., Galant, S., Machado, E., Affaticati, P., Jenett, A., Yamamoto, K. (2019) Mesencephalic origin of the inferior lobe in zebrafish. BMC Biology. 17:22.