PUBLICATION

Simultaneous B and T cell acute lymphoblastic leukemias in zebrafish driven by transgenic MYC: implications for oncogenesis and lymphopoiesis

Authors
Borga, C., Park, G., Foster, C., Burroughs-Garcia, J., Marchesin, M., Shah, R., Hasan, A., Ahmed, S.T., Bresolin, S., Batchelor, L., Scordino, T., Miles, R.R., Te Kronnie, G., Regens, J.L., Frazer, J.K.
ID
ZDB-PUB-180817-4
Date
2018
Source
Leukemia   33(2): 333-347 (Journal)
Registered Authors
Batchelor, Lance, Frazer, Kimble
Keywords
none
MeSH Terms
  • Animals
  • Animals, Genetically Modified
  • Cell Transformation, Neoplastic/genetics
  • Cell Transformation, Neoplastic/metabolism
  • Cell Transformation, Neoplastic/pathology*
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Lymphopoiesis*
  • Neoplasms, Multiple Primary/genetics
  • Neoplasms, Multiple Primary/metabolism
  • Neoplasms, Multiple Primary/pathology*
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/metabolism
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/pathology*
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/genetics
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/metabolism
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/pathology*
  • Proto-Oncogene Proteins c-myc/genetics
  • Proto-Oncogene Proteins c-myc/metabolism*
  • Zebrafish
PubMed
30111845 Full text @ Leukemia
Abstract
Precursor-B cell acute lymphoblastic leukemia (pre-B ALL) is the most common pediatric cancer, but there are no useful zebrafish pre-B ALL models. We describe the first highly- penetrant zebrafish pre-B ALL, driven by human MYC. Leukemias express B lymphoblast-specific genes and are distinct from T cell ALL (T-ALL)-which these fish also develop. Zebrafish pre-B ALL shares in vivo features and expression profiles with human pre-B ALL, and these profiles differ from zebrafish T-ALL or normal B and T cells. These animals also exhibit aberrant lymphocyte development. As the only robust zebrafish pre-B ALL model and only example where T-ALL also develops, this model can reveal differences between MYC-driven pre-B vs. T-ALL and be exploited to discover novel pre-B ALL therapies.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes