PUBLICATION

Principles of Functional Circuit Connectivity: Insights From Spontaneous Activity in the Zebrafish Optic Tectum

Authors
Marachlian, E., Avitan, L., Goodhill, G.J., Sumbre, G.
ID
ZDB-PUB-180707-2
Date
2018
Source
Frontiers in neural circuits   12: 46 (Review)
Registered Authors
Sumbre, Germán
Keywords
functional connectivity, optic tectum, sensory experience, spontaneous activity, two-photon calcium imaging, zebrafish
MeSH Terms
  • Animals
  • Larva/physiology
  • Neurons/physiology*
  • Photic Stimulation
  • Retina/physiology*
  • Superior Colliculi/physiology*
  • Visual Pathways/physiology*
  • Zebrafish/physiology
PubMed
29977193 Full text @ Front. Neural Circuits
Abstract
The brain is continuously active, even in the absence of external stimulation. In the optic tectum of the zebrafish larva, this spontaneous activity is spatially organized and reflects the circuit's functional connectivity. The structure of the spontaneous activity displayed patterns associated with aspects of the larva's preferences when engaging in complex visuo-motor behaviors, suggesting that the tectal circuit is adapted for the circuit's functional role in detecting visual cues and generating adequate motor behaviors. Further studies in sensory deprived larvae suggest that the basic structure of the functional connectivity patterns emerges even in the absence of retinal inputs, but that its fine structure is affected by visual experience.
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