PUBLICATION
The expression of fgfr3 in the zebrafish head
- Authors
- Ledwon, J.K., Turin, S.Y., Gosain, A.K., Topczewska, J.M.
- ID
- ZDB-PUB-180410-2
- Date
- 2018
- Source
- Gene expression patterns : GEP 29: 32-38 (Journal)
- Registered Authors
- Topczewska, Jolanta
- Keywords
- Bone cranium, Cartilage, Chondroclasts, Chondrocyte, Osteoblast, Osteoclasts, Zebrafish, fgfr3
- MeSH Terms
-
- Animals
- Brain/cytology
- Brain/metabolism*
- Cartilage/cytology
- Cartilage/metabolism*
- Cell Differentiation*
- Cells, Cultured
- Chondrocytes/cytology
- Chondrocytes/metabolism*
- Receptor, Fibroblast Growth Factor, Type 3/genetics*
- Signal Transduction
- Zebrafish/genetics
- Zebrafish/growth & development
- Zebrafish/metabolism*
- Zebrafish Proteins/genetics*
- PubMed
- 29630949 Full text @ Gene Expr. Patterns
Citation
Ledwon, J.K., Turin, S.Y., Gosain, A.K., Topczewska, J.M. (2018) The expression of fgfr3 in the zebrafish head. Gene expression patterns : GEP. 29:32-38.
Abstract
Fibroblast growth factor (FGF) signaling is essential for many developmental processes and plays a pivotal role in skeletal homeostasis, regeneration and wound healing. FGF signals through one of five tyrosine kinase receptors: Fgfr1a, -1b, -2, -3, -4. To characterize the expression of zebrafish fgfr3 from the larval stage to adulthood, we used RNAscope in situ hybridization on paraffin sections of the zebrafish head. Our study revealed spatial and temporal distribution of fgfr3 transcript in chondrocytes of the head cartilages, osteoblasts involved in bone formation, ventricular zone of the brain, undifferentiated mesenchymal cells of the skin, and lens epithelium of the eye. In general, the expression pattern of zebrafish fgfr3 is similar to the expression observed in higher vertebrates.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping