PUBLICATION
Modeling Alzheimer's and Other Age Related Human Diseases in Embryonic Systems
- Authors
- Lim, C.H., Mathuru, A.S.
- ID
- ZDB-PUB-180405-4
- Date
- 2017
- Source
- Journal of developmental biology 6(1): (Other)
- Registered Authors
- Mathuru, Ajay
- Keywords
- Alzheimer’s disease, CRY2, Caenorhabditis elegans, Danio rerio, Drosophila melanogaster, optogenetics
- MeSH Terms
- none
- PubMed
- 29615550 Full text @ J Dev Biol
Citation
Lim, C.H., Mathuru, A.S. (2017) Modeling Alzheimer's and Other Age Related Human Diseases in Embryonic Systems. Journal of developmental biology. 6(1).
Abstract
Modeling human disease in animals is an important strategy to discover potential methods of intervention. We suggest that there is much to be gained by employing a multi-model approach that takes advantage of different animal systems used in the laboratory simultaneously. We use the example of modeling Alzheimer's disease in Drosophila melanogaster, Caenorhabditis elegans, and Danio rerio to illustrate how such an approach can be employed to investigate the pathophysiology of the disease.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping