PUBLICATION

Optimal occlusion uniformly partitions red blood cells fluxes within a microvascular network

Authors
Chang, S.S., Tu, S., Baek, K.I., Pietersen, A., Liu, Y.H., Savage, V.M., Hwang, S.L., Hsiai, T.K., Roper, M.
ID
ZDB-PUB-171216-8
Date
2017
Source
PLoS Computational Biology   13: e1005892 (Journal)
Registered Authors
Baek, Kyung, Hwang, Sheng-Ping L.
Keywords
none
MeSH Terms
  • Hemorheology
  • Animals
  • Erythrocytes/physiology
  • Blood Flow Velocity/physiology
  • Microcirculation/physiology*
  • Zebrafish
  • Feedback, Physiological
  • Animals, Genetically Modified
  • Models, Cardiovascular*
  • Computational Biology
  • Microvessels/anatomy & histology
  • Microvessels/physiology*
(all 12)
PubMed
29244812 Full text @ PLoS Comput. Biol.
Abstract
In animals, gas exchange between blood and tissues occurs in narrow vessels, whose diameter is comparable to that of a red blood cell. Red blood cells must deform to squeeze through these narrow vessels, transiently blocking or occluding the vessels they pass through. Although the dynamics of vessel occlusion have been studied extensively, it remains an open question why microvessels need to be so narrow. We study occlusive dynamics within a model microvascular network: the embryonic zebrafish trunk. We show that pressure feedbacks created when red blood cells enter the finest vessels of the trunk act together to uniformly partition red blood cells through the microvasculature. Using mathematical models as well as direct observation, we show that these occlusive feedbacks are tuned throughout the trunk network to prevent the vessels closest to the heart from short-circuiting the network. Thus occlusion is linked with another open question of microvascular function: how are red blood cells delivered at the same rate to each micro-vessel? Our analysis shows that tuning of occlusive feedbacks increase the total dissipation within the network by a factor of 11, showing that uniformity of flows rather than minimization of transport costs may be prioritized by the microvascular network.
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Mutations / Transgenics
Allele Construct Type Affected Genomic Region
sd2TgTransgenic Insertion
    ta52b
      		Point Mutation
      y1TgTransgenic Insertion
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        Engineered Foreign Genes
        Marker Marker Type Name
        DsRedEFGDsRed
        EGFPEFGEGFP
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        Citation
        Chang, S.S., Tu, S., Baek, K.I., Pietersen, A., Liu, Y.H., Savage, V.M., Hwang, S.L., Hsiai, T.K., Roper, M. (2017) Optimal occlusion uniformly partitions red blood cells fluxes within a microvascular network. PLoS Computational Biology. 13:e1005892.